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12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation.

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Title: 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation.
Authors: Thomas CP; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, United Kingdom., Tyrrell VJ; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Burston JJ; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Johnson SRC; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Aldrovandi M; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Alvarez-Jarreta J; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Inglis R; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Leonard A; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Fice L; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Costales J; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Vidal-Puig A; Centro de Investigacion Principe Felipe, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Valencia 46012, Spain.; University of Cambridge Metabolic Research Laboratories Institute of Metabolic Science, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom., Protty M; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Guy C; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Andrews R; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Szomolay B; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Cossins BC; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Cardus Figueras A; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Carobbio S; Centro de Investigacion Principe Felipe, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Valencia 46012, Spain., Jones SA; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., O'Donnell VB; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Sep 09; Vol. 122 (36), pp. e2502640122. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Thomas+CP%22">Thomas CP</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tyrrell+VJ%22">Tyrrell VJ</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burston+JJ%22">Burston JJ</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Johnson+SRC%22">Johnson SRC</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Aldrovandi+M%22">Aldrovandi M</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Alvarez-Jarreta+J%22">Alvarez-Jarreta J</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Inglis+R%22">Inglis R</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Leonard+A%22">Leonard A</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fice+L%22">Fice L</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Costales+J%22">Costales J</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vidal-Puig+A%22">Vidal-Puig A</searchLink>; Centro de Investigacion Principe Felipe, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Valencia 46012, Spain.; University of Cambridge Metabolic Research Laboratories Institute of Metabolic Science, Addenbrookes Hospital, Cambridge CB2 0QQ, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Protty+M%22">Protty M</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Guy+C%22">Guy C</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Andrews+R%22">Andrews R</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Szomolay+B%22">Szomolay B</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cossins+BC%22">Cossins BC</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cardus+Figueras+A%22">Cardus Figueras A</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Carobbio+S%22">Carobbio S</searchLink>; Centro de Investigacion Principe Felipe, Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Valencia 46012, Spain.<br /><searchLink fieldCode="AU" term="%22Jones+SA%22">Jones SA</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.<br /><searchLink fieldCode="AU" term="%22O'Donnell+VB%22">O'Donnell VB</searchLink>; Systems Immunity Research Institute and Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Sep 09; Vol. 122 (36), pp. e2502640122. <i>Date of Electronic Publication: </i>2025 Sep 04.
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