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Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.

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Title: Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.
Authors: Kumowski N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Pabel S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Momin N; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ninh VK; University of California, San Diego Department of Medicine and Bioengineering, La Jolla, CA, USA., Stengel L; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.; Department of Cardiology, Kerckhoff Heart Center, Bad Nauheim, Germany., Mentkowski KI; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zheng Y; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lee IH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Matthias J; Abberior Instruments America, Bethesda, MD, USA., Wirth JO; Abberior Instruments America, Bethesda, MD, USA., Pulous FE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Seung H; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Paccalet A; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Muse CG; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ting KKY; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Delgado P; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lewis AJM; Radcliffe Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, and British Heart Foundation Centre of Research Excellence, Oxford, UK., Kaushal V; Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kreso A; Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Brown D; Program in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hayat S; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology Hypertension), RWTH Aachen, Medical Faculty, Aachen, Germany., Kramann R; Department of Medicine 2 (Nephrology, Rheumatology, Clinical Immunology Hypertension), RWTH Aachen, Medical Faculty, Aachen, Germany.; Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, Netherlands., Swirski FK; Cardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Naxerova K; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Blavatnik Institute, Department of Genetics, Harvard Medical School, Boston, MA, USA., Propheter DC; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Hooper LV; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX, USA., Moskowitz MA; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., King KR; University of California, San Diego Department of Medicine and Bioengineering, La Jolla, CA, USA., Rosenthal N; The Jackson Laboratory, Bar Harbor, ME, USA.; National Heart and Lung Institute, Imperial College, London, UK., Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Center for Inflammation Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany.
Source: Science (New York, N.Y.) [Science] 2025 Sep 04; Vol. 389 (6764), pp. 1043-1048. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.
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