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Acalabrutinib treatment for older (aged ≥80 years) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial.

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Title: Acalabrutinib treatment for older (aged ≥80 years) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial.
Authors: Simon F; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Ligtvoet R; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Bohn JP; Department of Internal Medicine V-Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria., Nösslinger T; Third Medical Department for Hematology and Oncology, Hanusch Krankenhaus Wien, Vienna, Austria., von Tresckow J; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Liersch R; Gemeinschaftspraxis für Hämatologie und Onkologie, Clemenshospital Münster, Münster, Germany., Gaska T; Brüderkrankenhaus St. Josef Paderborn, Klinik für Hämatologie und Onkologie, Paderborn, Germany., Jentsch-Ullrich K; Gemeinschaftspraxis für Hämatologie und Onkologie, Magdeburg, Germany., Gärtner M; Onkologisches Ambulanzzentrum Hannover, Hannover, Germany., Wolff T; OncoResearch Lerchenfeld, Hamburg, Germany., Schwaner I; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany., Wolf D; Department of Internal Medicine V-Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria., Schneider C; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany., Vehling-Kaiser U; Outpatient Clinic, Landshut, Germany., Ritgen M; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany., Spoer C; MVZ Klinikum Deggendorf, Deggendorf, Germany., Eckart M; Practice for Oncology and Hematology, Erlangen, Germany., Decker T; Oncological Practice, Ravensburg, Germany., Chakupurakal G; Praxis für Hämatologie und Onkologie, Koblenz, Germany., Schöttker B; Practice for Oncology and Hematology, Würzburg, Germany., Kisro J; Lübecker Onkologische Schwerpunktpraxis, Lübeck, Germany., Kreuzer KA; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Tausch E; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany., Stilgenbauer S; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany., Robrecht S; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Stumpf J; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Fink AM; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Fürstenau M; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Fischer K; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Goede V; Department of Oncogeriatrics, St Marien Hospital, Cologne, Germany., Hallek M; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany., Eichhorst B; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Source: Blood [Blood] 2025 Dec 25; Vol. 146 (26), pp. 3153-3162.
Publication Type: Clinical Trial, Phase II; Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Acalabrutinib treatment for older (aged ≥80 years) and/or frail patients with CLL: primary end point analysis of the CLL-Frail trial.
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  Data: <searchLink fieldCode="AU" term="%22Simon+F%22">Simon F</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ligtvoet+R%22">Ligtvoet R</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bohn+JP%22">Bohn JP</searchLink>; Department of Internal Medicine V-Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Nösslinger+T%22">Nösslinger T</searchLink>; Third Medical Department for Hematology and Oncology, Hanusch Krankenhaus Wien, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22von+Tresckow+J%22">von Tresckow J</searchLink>; Clinic for Hematology and Stem Cell Transplantation, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Liersch+R%22">Liersch R</searchLink>; Gemeinschaftspraxis für Hämatologie und Onkologie, Clemenshospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Gaska+T%22">Gaska T</searchLink>; Brüderkrankenhaus St. Josef Paderborn, Klinik für Hämatologie und Onkologie, Paderborn, Germany.<br /><searchLink fieldCode="AU" term="%22Jentsch-Ullrich+K%22">Jentsch-Ullrich K</searchLink>; Gemeinschaftspraxis für Hämatologie und Onkologie, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gärtner+M%22">Gärtner M</searchLink>; Onkologisches Ambulanzzentrum Hannover, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Wolff+T%22">Wolff T</searchLink>; OncoResearch Lerchenfeld, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schwaner+I%22">Schwaner I</searchLink>; Onkologische Schwerpunktpraxis Kurfürstendamm, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+D%22">Wolf D</searchLink>; Department of Internal Medicine V-Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Schneider+C%22">Schneider C</searchLink>; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Vehling-Kaiser+U%22">Vehling-Kaiser U</searchLink>; Outpatient Clinic, Landshut, Germany.<br /><searchLink fieldCode="AU" term="%22Ritgen+M%22">Ritgen M</searchLink>; Department II of Internal Medicine, University of Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Spoer+C%22">Spoer C</searchLink>; MVZ Klinikum Deggendorf, Deggendorf, Germany.<br /><searchLink fieldCode="AU" term="%22Eckart+M%22">Eckart M</searchLink>; Practice for Oncology and Hematology, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Decker+T%22">Decker T</searchLink>; Oncological Practice, Ravensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chakupurakal+G%22">Chakupurakal G</searchLink>; Praxis für Hämatologie und Onkologie, Koblenz, Germany.<br /><searchLink fieldCode="AU" term="%22Schöttker+B%22">Schöttker B</searchLink>; Practice for Oncology and Hematology, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kisro+J%22">Kisro J</searchLink>; Lübecker Onkologische Schwerpunktpraxis, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Kreuzer+KA%22">Kreuzer KA</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Tausch+E%22">Tausch E</searchLink>; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Stilgenbauer+S%22">Stilgenbauer S</searchLink>; Department of Internal Medicine III, Sektion CLL, Ulm University, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Robrecht+S%22">Robrecht S</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stumpf+J%22">Stumpf J</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fink+AM%22">Fink AM</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fürstenau+M%22">Fürstenau M</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+K%22">Fischer K</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Goede+V%22">Goede V</searchLink>; Department of Oncogeriatrics, St Marien Hospital, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hallek+M%22">Hallek M</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Eichhorst+B%22">Eichhorst B</searchLink>; Department I of Internal Medicine and Center of Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
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