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Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.

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Title: Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.
Authors: Scalvini L; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy., Tagliazucchi L; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Elisi GM; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy., Zappaterra D; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Moschella MG; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy; Clinical and Experimental Medicine (CEM) PhD Program, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy., Fantini S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy., Aiello D; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Guerrini R; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy., Albanese V; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy., Pacifico S; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy., Lopresti L; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy., Malpezzi G; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy; Clinical and Experimental Medicine (CEM) PhD Program, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy., Saporito G; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Ferrari S; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Lamesta M; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy; Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.) PhD in Precision Medicine, University of Palermo, Palermo, Italy., Losi L; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Pozzi C; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Via Luigi Sacconi 6, 50019, Sesto Fiorentino (FI), Italy., Mangani S; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy., Marverti G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy., Venturelli A; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., Ponterini G; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy., D'Arca D; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy. Electronic address: domenico.darca@unimore.it., Mor M; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy. Electronic address: marco.mor@unipr.it., Costi MP; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy. Electronic address: mariapaola.costi@unimore.it.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Dec 15; Vol. 300, pp. 118056. Date of Electronic Publication: 2025 Aug 12.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics.
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  Data: <searchLink fieldCode="AU" term="%22Scalvini+L%22">Scalvini L</searchLink>; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Tagliazucchi+L%22">Tagliazucchi L</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Elisi+GM%22">Elisi GM</searchLink>; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Zappaterra+D%22">Zappaterra D</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Moschella+MG%22">Moschella MG</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy; Clinical and Experimental Medicine (CEM) PhD Program, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Fantini+S%22">Fantini S</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Aiello+D%22">Aiello D</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Guerrini+R%22">Guerrini R</searchLink>; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Albanese+V%22">Albanese V</searchLink>; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Pacifico+S%22">Pacifico S</searchLink>; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Lopresti+L%22">Lopresti L</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Malpezzi+G%22">Malpezzi G</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. 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PhD in Precision Medicine, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Losi+L%22">Losi L</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Pozzi+C%22">Pozzi C</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy; Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP), Via Luigi Sacconi 6, 50019, Sesto Fiorentino (FI), Italy.<br /><searchLink fieldCode="AU" term="%22Mangani+S%22">Mangani S</searchLink>; Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2020, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Marverti+G%22">Marverti G</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Venturelli+A%22">Venturelli A</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Ponterini+G%22">Ponterini G</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22D'Arca+D%22">D'Arca D</searchLink>; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125, Modena, Italy. Electronic address: domenico.darca@unimore.it.<br /><searchLink fieldCode="AU" term="%22Mor+M%22">Mor M</searchLink>; Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy. Electronic address: marco.mor@unipr.it.<br /><searchLink fieldCode="AU" term="%22Costi+MP%22">Costi MP</searchLink>; Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy. Electronic address: mariapaola.costi@unimore.it.
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