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Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial.

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Title: Benefit-risk of colchicine and spironolactone in acute myocardial infarction: a prespecified generalised pairwise comparisons analysis of the CLEAR trial.
Authors: d'Entremont MA; Population Health Research Institute, Hamilton, Ontario, Canada marc-andre.dentremont@usherbrooke.ca.; Hamilton Health Sciences, Hamilton, Ontario, Canada.; Department of Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada., Jolly SS; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada., Alharthi F; Hamilton Health Sciences, Hamilton, Ontario, Canada., Shah B; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA., Austin D; Population Health Science Institute, Newcastle University, Newcastle upon Tyne, UK., Yi Q; University of Ottawa, Ottawa, Ontario, Canada., Storey RF; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Directorate of Cardiology and Cardiothoracic Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK., Bossard M; Luzerner Kantonsspital, Lucerne, Switzerland., Cornel J; Departement of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., Jaspers Focks J; Departement of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., Kedev S; University Clinic of Cardiology, Skopje, North Macedonia., Asani V; Clinical Hospital Tetovo, Tetovo, North Macedonia., Stankovic G; Department of Cardiology, Clinical Center of Serbia and Medical School of Belgrade, Belgrade, Serbia., Tsang M; Hamilton Health Sciences, Hamilton, Ontario, Canada., Valettas N; Hamilton Health Sciences, Hamilton, Ontario, Canada., Tyrwhitt J; Population Health Research Institute, Hamilton, Ontario, Canada., Betz J; Population Health Research Institute, Hamilton, Ontario, Canada., Lee SF; Population Health Research Institute, Hamilton, Ontario, Canada., Mian R; Population Health Research Institute, Hamilton, Ontario, Canada., Silvain J; Département de Cardiologie, UPMC Faculte de Medecine, Paris, France.; Département de Cardiologie, Assistance Publique - Hopitaux de Paris, Paris, France., Beygui F; Cardiology, Centre Hospitalier Universitaire de Caen, Caen, France., Czarnecki A; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Dehghani P; Prairie Vascular Research Inc, Regina, Saskatchewan, Canada., Cantor W; Southlake Regional Health Centre, Newmarket, Ontario, Canada., Lavi S; Department of Medicine, London Health Sciences, London, Ontario, Canada., Spratt JC; St George's Healthcare NHS Trust, London, UK., Belley-Côté EP; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada., Eikelboom JW; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada.
Source: Heart (British Cardiac Society) [Heart] 2026 Feb 23; Vol. 112 (6), pp. 326-332. Date of Electronic Publication: 2026 Feb 23.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study
Journal Info: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 9602087 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-201X (Electronic) Linking ISSN: 13556037 NLM ISO Abbreviation: Heart Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22d'Entremont+MA%22">d'Entremont MA</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada marc-andre.dentremont@usherbrooke.ca.; Hamilton Health Sciences, Hamilton, Ontario, Canada.; Department of Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Jolly+SS%22">Jolly SS</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Alharthi+F%22">Alharthi F</searchLink>; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Shah+B%22">Shah B</searchLink>; Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Austin+D%22">Austin D</searchLink>; Population Health Science Institute, Newcastle University, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Yi+Q%22">Yi Q</searchLink>; University of Ottawa, Ottawa, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Storey+RF%22">Storey RF</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.; Directorate of Cardiology and Cardiothoracic Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Bossard+M%22">Bossard M</searchLink>; Luzerner Kantonsspital, Lucerne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cornel+J%22">Cornel J</searchLink>; Departement of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jaspers+Focks+J%22">Jaspers Focks J</searchLink>; Departement of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kedev+S%22">Kedev S</searchLink>; University Clinic of Cardiology, Skopje, North Macedonia.<br /><searchLink fieldCode="AU" term="%22Asani+V%22">Asani V</searchLink>; Clinical Hospital Tetovo, Tetovo, North Macedonia.<br /><searchLink fieldCode="AU" term="%22Stankovic+G%22">Stankovic G</searchLink>; Department of Cardiology, Clinical Center of Serbia and Medical School of Belgrade, Belgrade, Serbia.<br /><searchLink fieldCode="AU" term="%22Tsang+M%22">Tsang M</searchLink>; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Valettas+N%22">Valettas N</searchLink>; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Tyrwhitt+J%22">Tyrwhitt J</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Betz+J%22">Betz J</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+SF%22">Lee SF</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mian+R%22">Mian R</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Silvain+J%22">Silvain J</searchLink>; Département de Cardiologie, UPMC Faculte de Medecine, Paris, France.; Département de Cardiologie, Assistance Publique - Hopitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Beygui+F%22">Beygui F</searchLink>; Cardiology, Centre Hospitalier Universitaire de Caen, Caen, France.<br /><searchLink fieldCode="AU" term="%22Czarnecki+A%22">Czarnecki A</searchLink>; Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Dehghani+P%22">Dehghani P</searchLink>; Prairie Vascular Research Inc, Regina, Saskatchewan, Canada.<br /><searchLink fieldCode="AU" term="%22Cantor+W%22">Cantor W</searchLink>; Southlake Regional Health Centre, Newmarket, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lavi+S%22">Lavi S</searchLink>; Department of Medicine, London Health Sciences, London, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Spratt+JC%22">Spratt JC</searchLink>; St George's Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Belley-Côté+EP%22">Belley-Côté EP</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Eikelboom+JW%22">Eikelboom JW</searchLink>; Population Health Research Institute, Hamilton, Ontario, Canada.; Hamilton Health Sciences, Hamilton, Ontario, Canada.
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  Data: <searchLink fieldCode="JN" term="%229602087%22">Heart (British Cardiac Society)</searchLink> [Heart] 2026 Feb 23; Vol. 112 (6), pp. 326-332. <i>Date of Electronic Publication: </i>2026 Feb 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Pub%2E+Group%22">BMJ Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9602087 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-201X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213556037%22">13556037 </searchLink><i>NLM ISO Abbreviation: </i>Heart <i>Subsets: </i>MEDLINE
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        Value: 10.1136/heartjnl-2025-326218
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        Text: English
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