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METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury.

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Title: METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury.
Authors: Hou C; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Zhang XR; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Wei J; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Wang JN; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Gao J; School of Medicine, Anhui University of Science and Technology, Huainan, Anhui, China., Wang ZJ; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Xie SS; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Chen T; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China., Sun T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Pu T; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Yu JT; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Suo XG; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Mei ZY; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China., Zhang FR; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China., Jin J; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China., Zhao WM; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China., Shen YX; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China., Meng XM; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
Source: Science immunology [Sci Immunol] 2025 Sep 05; Vol. 10 (111), pp. eadv4810. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: METTL1-mediated m<superscript>7</superscript>G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury.
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  Data: <searchLink fieldCode="AU" term="%22Hou+C%22">Hou C</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XR%22">Zhang XR</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Wei+J%22">Wei J</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Wang+JN%22">Wang JN</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Gao+J%22">Gao J</searchLink>; School of Medicine, Anhui University of Science and Technology, Huainan, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZJ%22">Wang ZJ</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Xie+SS%22">Xie SS</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Chen+T%22">Chen T</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Sun+T%22">Sun T</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Pu+T%22">Pu T</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Yu+JT%22">Yu JT</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Suo+XG%22">Suo XG</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Mei+ZY%22">Mei ZY</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhang+FR%22">Zhang FR</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Jin+J%22">Jin J</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Zhao+WM%22">Zhao WM</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.; Department of Nephrology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Shen+YX%22">Shen YX</searchLink>; School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Meng+XM%22">Meng XM</searchLink>; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2025 Sep 05; Vol. 10 (111), pp. eadv4810. <i>Date of Electronic Publication: </i>2025 Sep 05.
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              Text: 2025 Sep 05
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