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The "five-star matrix" for patient-centric drug discovery and development in neuroscience.

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Title: The "five-star matrix" for patient-centric drug discovery and development in neuroscience.
Authors: Pähler A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. Electronic address: axel.paehler@roche.com., O'Connor EC; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Binch H; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Dudal S; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Gobbi LC; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Lübbers T; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Olivares-Morales A; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Rodríguez Sarmiento RM; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Grether U; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Stahl M; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Pagano G; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland., Stepan AF; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. Electronic address: antonia.stepan@roche.com.
Source: Neuron [Neuron] 2025 Sep 17; Vol. 113 (18), pp. 2885-2909. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article; Review
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The "five-star matrix" for patient-centric drug discovery and development in neuroscience.
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  Data: <searchLink fieldCode="AU" term="%22Pähler+A%22">Pähler A</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. Electronic address: axel.paehler@roche.com.<br /><searchLink fieldCode="AU" term="%22O'Connor+EC%22">O'Connor EC</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Binch+H%22">Binch H</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dudal+S%22">Dudal S</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gobbi+LC%22">Gobbi LC</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lübbers+T%22">Lübbers T</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Olivares-Morales+A%22">Olivares-Morales A</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rodríguez+Sarmiento+RM%22">Rodríguez Sarmiento RM</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grether+U%22">Grether U</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stahl+M%22">Stahl M</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pagano+G%22">Pagano G</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stepan+AF%22">Stepan AF</searchLink>; Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, 4070 Basel, Switzerland. Electronic address: antonia.stepan@roche.com.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2025 Sep 17; Vol. 113 (18), pp. 2885-2909. <i>Date of Electronic Publication: </i>2025 Sep 04.
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