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Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.

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Title: Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.
Authors: Bohar B; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Thomas JP; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; UKRI MRC Laboratory of Medical Sciences, Hammersmith Hospital Campus, London, United Kingdom., Liu Y; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Brooks-Warburton J; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; Department of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, Hertford, United Kingdom.; Department of Gastroenterology, Lister Hospital, Stevenage, United Kingdom., Verstockt B; Department Gastroenterology & Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Powell N; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Korcsmaros T; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; NIHR Imperial BRC Organoid Facility, Imperial College London, London, United Kingdom., Modos D; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
Source: Inflammatory bowel diseases [Inflamm Bowel Dis] 2025 Oct 01; Vol. 31 (10), pp. 2665-2680.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-Specific Regulatory Network Rewiring in Inflammatory Bowel Disease: How Genetic Polymorphisms Divert Incoming Signals and Contribute to Disease Pathogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Bohar+B%22">Bohar B</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Thomas+JP%22">Thomas JP</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; UKRI MRC Laboratory of Medical Sciences, Hammersmith Hospital Campus, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brooks-Warburton+J%22">Brooks-Warburton J</searchLink>; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; Department of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, Hertford, United Kingdom.; Department of Gastroenterology, Lister Hospital, Stevenage, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Verstockt+B%22">Verstockt B</searchLink>; Department Gastroenterology & Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Powell+N%22">Powell N</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Korcsmaros+T%22">Korcsmaros T</searchLink>; Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; NIHR Imperial BRC Organoid Facility, Imperial College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Modos+D%22">Modos D</searchLink>; Gut Microbes and Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9508162 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1536-4844 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780998%22">10780998 </searchLink><i>NLM ISO Abbreviation: </i>Inflamm Bowel Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1093/ibd/izaf173
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      – Code: eng
        Text: English
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            – D: 01
              M: 10
              Text: 2025 Oct 01
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              Y: 2025
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