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Epstein-Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial.

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Title: Epstein-Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial.
Authors: Ellis J; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Infectious Diseases Institute, Kampala, Uganda. Electronic address: jayne.ellis1@lshtm.ac.uk., Groppelli E; Institute for Infection and Immunity, City St George's, University of London, London, UK., Doyle R; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK., Lawrence DS; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Meya DB; Infectious Diseases Institute, Kampala, Uganda; School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; University of Minnesota, Minneapolis, MN, USA., Boulware DR; University of Minnesota, Minneapolis, MN, USA., Mwandumba HC; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi., Kanyama C; University of North Carolina Project-Malawi, Lilongwe, Malawi; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hosseinipour MC; University of North Carolina Project-Malawi, Lilongwe, Malawi; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Meintjes G; Queen Mary University of London, London, UK; University of Cape Town, Cape Town, South Africa., Muzoora C; Mbarara University of Science and Technology, Mbarara, Uganda., Mosepele M; Botswana Harvard Health Partnership, Gaborone, Botswana., Ndhlovu CE; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Harrison TS; Institute for Infection and Immunity, City St George's, University of London, London, UK; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK., Jarvis JN; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana.
Corporate Authors: AMBITION Study Group
Source: The lancet. HIV [Lancet HIV] 2025 Oct; Vol. 12 (10), pp. e691-e700. Date of Electronic Publication: 2025 Sep 04.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
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  Data: Epstein-Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Ellis+J%22">Ellis J</searchLink>; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Infectious Diseases Institute, Kampala, Uganda. Electronic address: jayne.ellis1@lshtm.ac.uk.<br /><searchLink fieldCode="AU" term="%22Groppelli+E%22">Groppelli E</searchLink>; Institute for Infection and Immunity, City St George's, University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Doyle+R%22">Doyle R</searchLink>; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Lawrence+DS%22">Lawrence DS</searchLink>; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Meya+DB%22">Meya DB</searchLink>; Infectious Diseases Institute, Kampala, Uganda; School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Boulware+DR%22">Boulware DR</searchLink>; University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mwandumba+HC%22">Mwandumba HC</searchLink>; Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Kanyama+C%22">Kanyama C</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Hosseinipour+MC%22">Hosseinipour MC</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi; School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Meintjes+G%22">Meintjes G</searchLink>; Queen Mary University of London, London, UK; University of Cape Town, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Muzoora+C%22">Muzoora C</searchLink>; Mbarara University of Science and Technology, Mbarara, Uganda.<br /><searchLink fieldCode="AU" term="%22Mosepele+M%22">Mosepele M</searchLink>; Botswana Harvard Health Partnership, Gaborone, Botswana.<br /><searchLink fieldCode="AU" term="%22Ndhlovu+CE%22">Ndhlovu CE</searchLink>; Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Harrison+TS%22">Harrison TS</searchLink>; Institute for Infection and Immunity, City St George's, University of London, London, UK; MRC Centre for Medical Mycology, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Jarvis+JN%22">Jarvis JN</searchLink>; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK; Botswana Harvard Health Partnership, Gaborone, Botswana.
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  Data: <searchLink fieldCode="JN" term="%22101645355%22">The lancet. HIV</searchLink> [Lancet HIV] 2025 Oct; Vol. 12 (10), pp. e691-e700. <i>Date of Electronic Publication: </i>2025 Sep 04.
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      – TitleFull: Epstein-Barr virus and cytomegalovirus co-infections and mortality risk in patients with HIV-associated cryptococcal meningitis: a post-hoc analysis of a prospective nested cohort in the AMBITION-cm randomised controlled trial.
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