Treatment effects in orthopaedic trials are underestimated by applying patient-level PRO thresholds for meaningful differences at the group level.

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Title: Treatment effects in orthopaedic trials are underestimated by applying patient-level PRO thresholds for meaningful differences at the group level.
Authors: Hamilton DF; Research Centre for Health, Glasgow Caledonian University, Glasgow, UK., Giesinger K; Department of Orthopaedic Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland., Giesinger JM; Medical University of Innsbruck, University Hospital of Psychiatry II, Innsbruck, Austria.
Source: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA [Knee Surg Sports Traumatol Arthrosc] 2025 Nov; Vol. 33 (11), pp. 3739-3743. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: Germany NLM ID: 9314730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7347 (Electronic) Linking ISSN: 09422056 NLM ISO Abbreviation: Knee Surg Sports Traumatol Arthrosc Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Treatment effects in orthopaedic trials are underestimated by applying patient-level PRO thresholds for meaningful differences at the group level.
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  Data: <searchLink fieldCode="AU" term="%22Hamilton+DF%22">Hamilton DF</searchLink>; Research Centre for Health, Glasgow Caledonian University, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Giesinger+K%22">Giesinger K</searchLink>; Department of Orthopaedic Surgery, Kantonsspital St. Gallen, St. Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Giesinger+JM%22">Giesinger JM</searchLink>; Medical University of Innsbruck, University Hospital of Psychiatry II, Innsbruck, Austria.
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  Data: <searchLink fieldCode="JN" term="%229314730%22">Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</searchLink> [Knee Surg Sports Traumatol Arthrosc] 2025 Nov; Vol. 33 (11), pp. 3739-3743. <i>Date of Electronic Publication: </i>2025 Sep 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>9314730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1433-7347 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209422056%22">09422056 </searchLink><i>NLM ISO Abbreviation: </i>Knee Surg Sports Traumatol Arthrosc <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/ksa.12805
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      – Code: eng
        Text: English
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        StartPage: 3739
    Titles:
      – TitleFull: Treatment effects in orthopaedic trials are underestimated by applying patient-level PRO thresholds for meaningful differences at the group level.
        Type: main
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            NameFull: Hamilton DF
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            NameFull: Giesinger K
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            NameFull: Giesinger JM
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            – D: 01
              M: 11
              Text: 2025 Nov
              Type: published
              Y: 2025
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            – Type: issn-electronic
              Value: 1433-7347
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              Value: 33
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              Value: 11
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            – TitleFull: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
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