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Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial.

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Title: Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial.
Authors: Post CCB; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: c.c.b.post@lumc.nl., de Boer SM; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands., Powell ME; Department of Clinical Oncology, Barts Health NHS Trust, London, UK., Mileshkin L; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Katsaros D; Department of Surgical Sciences and Gynaecology, Città della Salute and S Anna Hospital, Turin, Italy., Bessette P; Department of Gynaecologic Oncology, University of Sherbrooke, Sherbrooke, QC, Canada., Leary A; Department of Cancer Medicine and Gynaecological Tumours Translational Research Lab, Gustave Roussy Cancer Centre, INSERM U981, Université Paris Saclay, Villejuif, France., Ottevanger PB; Department of Medical Oncology, Radboudumc, Nijmegen, Netherlands., McCormack M; Department of Clinical Oncology, University College Hospital London, London, UK., Khaw P; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., D'Amico R; Department of Radiation Oncology, Azienda Socio Sanitaria Territoriale, Lecco, Italy., Fyles A; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada., Chargari C; Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris, France., Kitchener HC; Institute of Cancer Sciences, University of Manchester, Manchester, UK., Do V; Liverpool Cancer Therapy Centre, Sydney, NSW, Australia., Lissoni A; Department of Obstetrics and Gynaecology, IRCCS San Gerardo dei Tintori, Monza, Italy., Provencher D; Department of Gynaecologic Oncology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada., Genestie C; Department of Pathology, Gustave Roussy Cancer Centre, Villejuif, France., Nijman HW; Department of Gynaecologic Oncology, University Medical Centre Groningen, Groningen, Netherlands., Whitmarsh K; Department of Radiation Oncology, The Clatterbridge Cancer Centre NHS Trust, Liverpool, UK., Jürgenliemk-Schulz IM; Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, Netherlands., Feeney A; Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, UK., Lutgens LCHW; MAASTRO Clinic Radiation Oncology, Maastricht, Netherlands., Bouma J; Central Data Management and Trial Coordination, Comprehensive Cancer Centre Netherlands, Rotterdam, Netherlands., Leon-Castillo A; Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands., Nout RA; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands., Putter H; Department of Medical Statistics, Leiden University Medical Centre, Leiden, Netherlands., Bosse T; Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands., Creutzberg CL; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands.
Source: The Lancet. Oncology [Lancet Oncol] 2025 Oct; Vol. 26 (10), pp. 1370-1381. Date of Electronic Publication: 2025 Sep 05.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial; Multicenter Study; Comparative Study
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial.
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  Data: <searchLink fieldCode="AU" term="%22Post+CCB%22">Post CCB</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands. Electronic address: c.c.b.post@lumc.nl.<br /><searchLink fieldCode="AU" term="%22de+Boer+SM%22">de Boer SM</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Powell+ME%22">Powell ME</searchLink>; Department of Clinical Oncology, Barts Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Mileshkin+L%22">Mileshkin L</searchLink>; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Katsaros+D%22">Katsaros D</searchLink>; Department of Surgical Sciences and Gynaecology, Città della Salute and S Anna Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Bessette+P%22">Bessette P</searchLink>; Department of Gynaecologic Oncology, University of Sherbrooke, Sherbrooke, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Leary+A%22">Leary A</searchLink>; Department of Cancer Medicine and Gynaecological Tumours Translational Research Lab, Gustave Roussy Cancer Centre, INSERM U981, Université Paris Saclay, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ottevanger+PB%22">Ottevanger PB</searchLink>; Department of Medical Oncology, Radboudumc, Nijmegen, Netherlands.<br /><searchLink fieldCode="AU" term="%22McCormack+M%22">McCormack M</searchLink>; Department of Clinical Oncology, University College Hospital London, London, UK.<br /><searchLink fieldCode="AU" term="%22Khaw+P%22">Khaw P</searchLink>; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22D'Amico+R%22">D'Amico R</searchLink>; Department of Radiation Oncology, Azienda Socio Sanitaria Territoriale, Lecco, Italy.<br /><searchLink fieldCode="AU" term="%22Fyles+A%22">Fyles A</searchLink>; Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Chargari+C%22">Chargari C</searchLink>; Department of Radiation Oncology, Gustave Roussy Cancer Campus, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kitchener+HC%22">Kitchener HC</searchLink>; Institute of Cancer Sciences, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Do+V%22">Do V</searchLink>; Liverpool Cancer Therapy Centre, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Lissoni+A%22">Lissoni A</searchLink>; Department of Obstetrics and Gynaecology, IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Provencher+D%22">Provencher D</searchLink>; Department of Gynaecologic Oncology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Genestie+C%22">Genestie C</searchLink>; Department of Pathology, Gustave Roussy Cancer Centre, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Nijman+HW%22">Nijman HW</searchLink>; Department of Gynaecologic Oncology, University Medical Centre Groningen, Groningen, Netherlands.<br /><searchLink fieldCode="AU" term="%22Whitmarsh+K%22">Whitmarsh K</searchLink>; Department of Radiation Oncology, The Clatterbridge Cancer Centre NHS Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Jürgenliemk-Schulz+IM%22">Jürgenliemk-Schulz IM</searchLink>; Department of Radiation Oncology, University Medical Centre Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Feeney+A%22">Feeney A</searchLink>; Cancer Research UK and UCL Cancer Trials Centre, UCL Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Lutgens+LCHW%22">Lutgens LCHW</searchLink>; MAASTRO Clinic Radiation Oncology, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bouma+J%22">Bouma J</searchLink>; Central Data Management and Trial Coordination, Comprehensive Cancer Centre Netherlands, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Leon-Castillo+A%22">Leon-Castillo A</searchLink>; Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Nout+RA%22">Nout RA</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Putter+H%22">Putter H</searchLink>; Department of Medical Statistics, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Bosse+T%22">Bosse T</searchLink>; Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands.<br /><searchLink fieldCode="AU" term="%22Creutzberg+CL%22">Creutzberg CL</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, Netherlands.
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  Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2025 Oct; Vol. 26 (10), pp. 1370-1381. <i>Date of Electronic Publication: </i>2025 Sep 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE
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