Risks for Adverse Events by Sex and Age After Prescription Opioid Dose Reduction: A Secondary Analysis Across 8 U.S. Health Systems.

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Title: Risks for Adverse Events by Sex and Age After Prescription Opioid Dose Reduction: A Secondary Analysis Across 8 U.S. Health Systems.
Authors: Metz VE; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California. Electronic address: verena.e.metz@kp.org., Palzes VA; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California., Binswanger IA; Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Colorado Permanente Medical Group, Denver, Colorado; Department of Health Systems Sciences, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California; Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, Colorado., Altschuler A; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California., Poulsen MN; Department of Population Health Sciences, Geisinger, Danville, Pennsylvania., Ahmedani BK; Center for Health Policy & Health Services Research, Henry Ford Health, Detroit, Michigan., Andrade SE; Meyers Primary Care Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts., Clark RE; Department of Family Medicine and Community Health, University of Massachusetts Chan School of Medicine, Worcester, Massachusetts., Hechter RC; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California., Horberg MA; Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Washington, District of Columbia., Sanchez K; Baylor Scott & White Research Institute, Dallas, Texas, and School of Social Work, University of Texas at Arlington, Arlington, Texas., Bailey SR; Department of Family Medicine, Oregon Health & Science University, Portland, Oregon., Stephens KA; Department of Family Medicine, University of Washington, Seattle, Washington., Rubinstein AL; Department of Pain Medicine, The Permanente Medical Group, Santa Rosa, California., Campbell CI; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California.
Source: American journal of preventive medicine [Am J Prev Med] 2025 Dec; Vol. 69 (6), pp. 108085. Date of Electronic Publication: 2025 Sep 06.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8704773 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2607 (Electronic) Linking ISSN: 07493797 NLM ISO Abbreviation: Am J Prev Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Metz+VE%22">Metz VE</searchLink>; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California. Electronic address: verena.e.metz@kp.org.<br /><searchLink fieldCode="AU" term="%22Palzes+VA%22">Palzes VA</searchLink>; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California.<br /><searchLink fieldCode="AU" term="%22Binswanger+IA%22">Binswanger IA</searchLink>; Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Colorado Permanente Medical Group, Denver, Colorado; Department of Health Systems Sciences, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, California; Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, Colorado.<br /><searchLink fieldCode="AU" term="%22Altschuler+A%22">Altschuler A</searchLink>; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California.<br /><searchLink fieldCode="AU" term="%22Poulsen+MN%22">Poulsen MN</searchLink>; Department of Population Health Sciences, Geisinger, Danville, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ahmedani+BK%22">Ahmedani BK</searchLink>; Center for Health Policy & Health Services Research, Henry Ford Health, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Andrade+SE%22">Andrade SE</searchLink>; Meyers Primary Care Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Clark+RE%22">Clark RE</searchLink>; Department of Family Medicine and Community Health, University of Massachusetts Chan School of Medicine, Worcester, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hechter+RC%22">Hechter RC</searchLink>; Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California.<br /><searchLink fieldCode="AU" term="%22Horberg+MA%22">Horberg MA</searchLink>; Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States, Washington, District of Columbia.<br /><searchLink fieldCode="AU" term="%22Sanchez+K%22">Sanchez K</searchLink>; Baylor Scott & White Research Institute, Dallas, Texas, and School of Social Work, University of Texas at Arlington, Arlington, Texas.<br /><searchLink fieldCode="AU" term="%22Bailey+SR%22">Bailey SR</searchLink>; Department of Family Medicine, Oregon Health & Science University, Portland, Oregon.<br /><searchLink fieldCode="AU" term="%22Stephens+KA%22">Stephens KA</searchLink>; Department of Family Medicine, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Rubinstein+AL%22">Rubinstein AL</searchLink>; Department of Pain Medicine, The Permanente Medical Group, Santa Rosa, California.<br /><searchLink fieldCode="AU" term="%22Campbell+CI%22">Campbell CI</searchLink>; Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, California.
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