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Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.

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Title: Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
Authors: Wingo AP; VA Northern California Healthcare System, Mather, CA, USA. apwingo@health.ucdavis.edu.; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA. apwingo@health.ucdavis.edu., Liu Y; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Vattathil SM; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Gerasimov ES; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA., Mei Z; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA., Ravindran SP; Department of Psychiatry, Emory University, Atlanta, GA, USA., Liu J; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA., Shantaraman A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA., Seifar F; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA., Wang E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhang B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reddy J; Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL, USA., Allen M; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA., Ertekin-Taner N; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA., Fox EJ; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA., Duong DM; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA., Epstein MP; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Cutler DJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., Levey AI; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA., Wingo TS; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA. twingo@health.ucdavis.edu.; Alzheimer's Disease Research Center, School of Medicine, University of California, Davis, Sacramento, CA, USA. twingo@health.ucdavis.edu.
Source: Nature genetics [Nat Genet] 2025 Sep; Vol. 57 (9), pp. 2156-2165. Date of Electronic Publication: 2025 Sep 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
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  Data: Multiancestry brain pQTL fine-mapping and integration with genome-wide association studies of 21 neurologic and psychiatric conditions.
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  Data: <searchLink fieldCode="AU" term="%22Wingo+AP%22">Wingo AP</searchLink>; VA Northern California Healthcare System, Mather, CA, USA. apwingo@health.ucdavis.edu.; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA. apwingo@health.ucdavis.edu.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Vattathil+SM%22">Vattathil SM</searchLink>; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gerasimov+ES%22">Gerasimov ES</searchLink>; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mei+Z%22">Mei Z</searchLink>; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ravindran+SP%22">Ravindran SP</searchLink>; Department of Psychiatry, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Psychiatry, School of Medicine, University of California, Davis, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shantaraman+A%22">Shantaraman A</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Seifar+F%22">Seifar F</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+E%22">Wang E</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+J%22">Reddy J</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Allen+M%22">Allen M</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ertekin-Taner+N%22">Ertekin-Taner N</searchLink>; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22De+Jager+PL%22">De Jager PL</searchLink>; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Fox+EJ%22">Fox EJ</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Duong+DM%22">Duong DM</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+MP%22">Epstein MP</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cutler+DJ%22">Cutler DJ</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Levey+AI%22">Levey AI</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Seyfried+NT%22">Seyfried NT</searchLink>; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA.; Goizueta Alzheimer's Disease Research Center, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wingo+TS%22">Wingo TS</searchLink>; Department of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA. twingo@health.ucdavis.edu.; Alzheimer's Disease Research Center, School of Medicine, University of California, Davis, Sacramento, CA, USA. twingo@health.ucdavis.edu.
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