Efficacy and in vitro activity of gepotidacin against bacterial uropathogens, including subsets with molecularly characterized resistance mechanisms and genotypes/epidemiological clones, in females with uncomplicated urinary tract infections: results from two global, pivotal, phase 3 trials (EAGLE-2 and EAGLE-3).

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Title: Efficacy and in vitro activity of gepotidacin against bacterial uropathogens, including subsets with molecularly characterized resistance mechanisms and genotypes/epidemiological clones, in females with uncomplicated urinary tract infections: results from two global, pivotal, phase 3 trials (EAGLE-2 and EAGLE-3).
Authors: Scangarella-Oman NE; GSK, Collegeville, Pennsylvania, USA., Butler DL; GSK, Collegeville, Pennsylvania, USA., Breton J; GSK, Collegeville, Pennsylvania, USA., Brown D; GSK, Collegeville, Pennsylvania, USA., Kasapidis C; GSK, Collegeville, Pennsylvania, USA., Sheets AJ; GSK, Collegeville, Pennsylvania, USA.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2025 Oct; Vol. 69 (10), pp. e0163924. Date of Electronic Publication: 2025 Sep 09.
Publication Type: Journal Article; Clinical Trial, Phase III
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1098-6596
DOI:10.1128/aac.01639-24