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Emerging strategies, applications and challenges of targeting NAD+ in the clinic.

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Title: Emerging strategies, applications and challenges of targeting NAD+ in the clinic.
Authors: Zhang J; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; Key Laboratory of Oral Health Research in Hunan Province, Xiangya School of Stomatology, Central South University, Hu'nan, China.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway., Wang HL; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway., Lautrup S; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway., Nilsen HL; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development (CRESCO), University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, Oslo, Norway., Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Watne LO; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway.; Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway., Selbæk G; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway., Wu LE; School of Biomedical Sciences, UNSW Sydney, Sydney, New South Wales, Australia., Omland T; Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, Oslo, Norway., Pirinen E; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Cheung TC; Hong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China., Wang J; Hong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China., Ziegler M; Department of Biomedicine, University of Bergen, Bergen, Norway., Tysnes OB; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway., Zapata-Pérez R; Group of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia, Guadalupe de Maciascoque, Murcia, Spain., Bruzzone S; Department of Experimental Medicine, Section of Biochemistry, University of Genova, Genova, Italy., Canto C; Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Deleidi M; Mechanisms and Therapy of Genetic Brain Diseases Institut Imagine, INSERM UMR 1163- Paris Cite' University, Paris, France., Janssens GE; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Houtkooper RH; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Scheibye-Knudsen M; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark., Koshizaka M; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan., Yokote K; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan., Verdin E; UCSF Department of Medicine, San Francisco, CA, USA.; Buck Institute for Research on Aging, Novato, CA, USA., Bohr VA; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.; Section on DNA Repair, National Institute on Aging, Baltimore, MD, USA., Tzoulis C; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway.; K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway., Sinclair DA; Department of Genetics, Blavatnik Institute, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA., Fang EF; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. e.f.fang@medisin.uio.no.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway. e.f.fang@medisin.uio.no.
Source: Nature aging [Nat Aging] 2025 Sep; Vol. 5 (9), pp. 1704-1731. Date of Electronic Publication: 2025 Sep 09.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Emerging strategies, applications and challenges of targeting NAD<superscript>+</superscript> in the clinic.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; Key Laboratory of Oral Health Research in Hunan Province, Xiangya School of Stomatology, Central South University, Hu'nan, China.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Wang+HL%22">Wang HL</searchLink>; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Lautrup+S%22">Lautrup S</searchLink>; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nilsen+HL%22">Nilsen HL</searchLink>; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development (CRESCO), University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Treebak+JT%22">Treebak JT</searchLink>; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Watne+LO%22">Watne LO</searchLink>; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Lørenskog, Norway.; Department of Geriatric Medicine, Akershus University Hospital, Lørenskog, Norway.<br /><searchLink fieldCode="AU" term="%22Selbæk+G%22">Selbæk G</searchLink>; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.; Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.<br /><searchLink fieldCode="AU" term="%22Wu+LE%22">Wu LE</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Omland+T%22">Omland T</searchLink>; Department of Cardiology, Akershus University Hospital, Lørenskog, Norway.; K.G. Jebsen Center for Cardiac Biomarkers, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Pirinen+E%22">Pirinen E</searchLink>; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Cheung+TC%22">Cheung TC</searchLink>; Hong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Hong Kong Longevity Science Laboratory Limited, Hong Kong Science Park, Pak Shek Kok, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Ziegler+M%22">Ziegler M</searchLink>; Department of Biomedicine, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Tysnes+OB%22">Tysnes OB</searchLink>; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Zapata-Pérez+R%22">Zapata-Pérez R</searchLink>; Group of Metabolism and Gene Regulation, UCAM HiTech Sport & Health Innovation Hub, Universidad Católica de Murcia, Guadalupe de Maciascoque, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Bruzzone+S%22">Bruzzone S</searchLink>; Department of Experimental Medicine, Section of Biochemistry, University of Genova, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Canto+C%22">Canto C</searchLink>; Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deleidi+M%22">Deleidi M</searchLink>; Mechanisms and Therapy of Genetic Brain Diseases Institut Imagine, INSERM UMR 1163- Paris Cite' University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Janssens+GE%22">Janssens GE</searchLink>; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Houtkooper+RH%22">Houtkooper RH</searchLink>; Laboratory Genetic Metabolic Diseases, Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM), Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Scheibye-Knudsen+M%22">Scheibye-Knudsen M</searchLink>; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Koshizaka+M%22">Koshizaka M</searchLink>; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Yokote+K%22">Yokote K</searchLink>; Department of Endocrinology, Hematology and Gerontology, Graduate School of Medicine, Chiba University, Chiba, Japan.; Department of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Verdin+E%22">Verdin E</searchLink>; UCSF Department of Medicine, San Francisco, CA, USA.; Buck Institute for Research on Aging, Novato, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bohr+VA%22">Bohr VA</searchLink>; Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.; Section on DNA Repair, National Institute on Aging, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Tzoulis+C%22">Tzoulis C</searchLink>; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway.; K.G. Jebsen Center for Translational Research in Parkinson's disease, University of Bergen, Bergen, Norway.<br /><searchLink fieldCode="AU" term="%22Sinclair+DA%22">Sinclair DA</searchLink>; Department of Genetics, Blavatnik Institute, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fang+EF%22">Fang EF</searchLink>; Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. e.f.fang@medisin.uio.no.; The Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian National anti-Alzheimer's Disease (NO-AD) Networks, Oslo, Norway. e.f.fang@medisin.uio.no.
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