Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization.
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| Title: | Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization. |
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| Authors: | Shi Z; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Guddneppanavar R; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Winn BA; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., MacDonough MT; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., George CS; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Wang Y; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Zimmer M; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Gerberich J; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America., Winters A; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America., Lin E; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America., Maguire CJ; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Ford J; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Hamel E; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States of America., Mason RP; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America., Trawick ML; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America., Pinney KG; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America. |
| Source: | RSC medicinal chemistry [RSC Med Chem] 2025 Aug 28. Date of Electronic Publication: 2025 Aug 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40927638 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Guddneppanavar+R%22">Guddneppanavar R</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Winn+BA%22">Winn BA</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22MacDonough+MT%22">MacDonough MT</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22George+CS%22">George CS</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Zimmer+M%22">Zimmer M</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Gerberich+J%22">Gerberich J</searchLink>; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America.<br /><searchLink fieldCode="AU" term="%22Winters+A%22">Winters A</searchLink>; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America.<br /><searchLink fieldCode="AU" term="%22Lin+E%22">Lin E</searchLink>; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America.<br /><searchLink fieldCode="AU" term="%22Maguire+CJ%22">Maguire CJ</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Ford+J%22">Ford J</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Hamel+E%22">Hamel E</searchLink>; Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States of America.<br /><searchLink fieldCode="AU" term="%22Mason+RP%22">Mason RP</searchLink>; Prognostic Imaging Research Laboratory, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States of America.<br /><searchLink fieldCode="AU" term="%22Trawick+ML%22">Trawick ML</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America.<br /><searchLink fieldCode="AU" term="%22Pinney+KG%22">Pinney KG</searchLink>; Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, United States of America. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101759460%22">RSC medicinal chemistry</searchLink> [RSC Med Chem] 2025 Aug 28. <i>Date of Electronic Publication: </i>2025 Aug 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Royal+Society+of+Chemistry%22">Royal Society of Chemistry </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101759460 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2632-8682 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226328682%22">26328682 </searchLink><i>NLM ISO Abbreviation: </i>RSC Med Chem |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40927638 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1039/d5md00564g Languages: – Code: eng Text: English Titles: – TitleFull: Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shi Z – PersonEntity: Name: NameFull: Guddneppanavar R – PersonEntity: Name: NameFull: Winn BA – PersonEntity: Name: NameFull: MacDonough MT – PersonEntity: Name: NameFull: George CS – PersonEntity: Name: NameFull: Wang Y – PersonEntity: Name: NameFull: Zimmer M – PersonEntity: Name: NameFull: Gerberich J – PersonEntity: Name: NameFull: Winters A – PersonEntity: Name: NameFull: Lin E – PersonEntity: Name: NameFull: Maguire CJ – PersonEntity: Name: NameFull: Ford J – PersonEntity: Name: NameFull: Hamel E – PersonEntity: Name: NameFull: Mason RP – PersonEntity: Name: NameFull: Trawick ML – PersonEntity: Name: NameFull: Pinney KG IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 08 Text: 2025 Aug 28 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2632-8682 Titles: – TitleFull: RSC medicinal chemistry Type: main |
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