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Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer.

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Title: Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer.
Authors: Fu T; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Jin X; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., He M; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Chen YY; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Yang YS; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Chen L; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Zhang HY; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Fan L; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Wu J; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Wang ZH; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China., Chu YW; Department of Immunology, Shanghai Medical School, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China., Liu RH; Shanghai Fifth People's Hospital, Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 201100, P. R. China., Jiang YZ; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.; Shanghai Academy of Natural Sciences (SANS), Fudan University, Shanghai 201203, P. R. China., Shao ZM; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.
Source: Science translational medicine [Sci Transl Med] 2025 Sep 10; Vol. 17 (815), pp. eadj7808. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Interferon-induced senescent CD8<superscript>+</superscript> T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Fu+T%22">Fu T</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Jin+X%22">Jin X</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22He+M%22">He M</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Yang+YS%22">Yang YS</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Zhang+HY%22">Zhang HY</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Fan+L%22">Fan L</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Wang+ZH%22">Wang ZH</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chu+YW%22">Chu YW</searchLink>; Department of Immunology, Shanghai Medical School, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China.<br /><searchLink fieldCode="AU" term="%22Liu+RH%22">Liu RH</searchLink>; Shanghai Fifth People's Hospital, Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 201100, P. R. China.<br /><searchLink fieldCode="AU" term="%22Jiang+YZ%22">Jiang YZ</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.; Shanghai Academy of Natural Sciences (SANS), Fudan University, Shanghai 201203, P. R. China.<br /><searchLink fieldCode="AU" term="%22Shao+ZM%22">Shao ZM</searchLink>; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, Shanghai 200032, P. R. China.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Sep 10; Vol. 17 (815), pp. eadj7808. <i>Date of Electronic Publication: </i>2025 Sep 10.
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              Text: 2025 Sep 10
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