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Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).

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Title: Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).
Authors: Redline S; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Li D; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts., Javaheri S; Division of Pulmonary and Sleep Medicine, Bethesda North Hospital, Cincinnati, Ohio., Patel SR; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Parthasarathy S; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona., Fang JC; Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, Utah., Brown LK; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico., Dunlap M; Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio., Badr MS; Department of Medicine, School of Medicine, Wayne State University, Detroit, Michigan., Shah N; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Chi L; Department of Neurology, Sleep Medicine Center, and., Majid R; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, McGovern Medical School, UT Health, Houston, Texas., Teodorescu M; Department of Medicine and Wisconsin Institute for Sleep and Consciousness and., Stewart G; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Hsich E; Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio., Polonsky T; Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois., Vader J; Cardiology Division, Department of Internal Medicine, School of Medicine, Washington University, St. Louis, Missouri., Johnson MR; Department of Medicine, Heart Failure and Transplant Cardiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Auckley D; Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio., Yaggi HK; Department of Medicine, Yale University, New Haven, Connecticut., Kao A; St. Luke's Mid America Heart Institute, Kansas City, Missouri., Azarbarzin A; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Alex R; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Rueschman M; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Wolfe L; Feinberg School of Medicine, Northwestern University, Chicago, Illinois., Gottlieb DJ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Medical Service, VA Boston Healthcare System, Boston, Massachusetts., Sands SA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Zee PC; Department of Neurology., Mehra R; Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington., Mokhlesi B; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois., Khayat R; Division of Pulmonary, Allergy, and Critical Care, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania., Lewis EF; Division of Cardiology, Department of Medicine, Stanford University, Palo Alto, California; and., Abraham WT; Division of Cardiovascular Medicine and Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, Ohio., Wang R; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts.
Source: Annals of the American Thoracic Society [Ann Am Thorac Soc] 2025 Dec; Vol. 22 (12), pp. 1951-1960.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 101600811 Publication Model: Print Cited Medium: Internet ISSN: 2325-6621 (Electronic) Linking ISSN: 23256621 NLM ISO Abbreviation: Ann Am Thorac Soc Subsets: MEDLINE
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  Data: Nocturnal Oxygen Therapy for Central Sleep Apnea in Patients with Heart Failure: A Multisite, Double-Blind, Sham-controlled Randomized Clinical Trial (LOFT-HF).
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  Data: <searchLink fieldCode="AU" term="%22Redline+S%22">Redline S</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Li+D%22">Li D</searchLink>; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Javaheri+S%22">Javaheri S</searchLink>; Division of Pulmonary and Sleep Medicine, Bethesda North Hospital, Cincinnati, Ohio.<br /><searchLink fieldCode="AU" term="%22Patel+SR%22">Patel SR</searchLink>; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Parthasarathy+S%22">Parthasarathy S</searchLink>; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona.<br /><searchLink fieldCode="AU" term="%22Fang+JC%22">Fang JC</searchLink>; Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, Utah.<br /><searchLink fieldCode="AU" term="%22Brown+LK%22">Brown LK</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.<br /><searchLink fieldCode="AU" term="%22Dunlap+M%22">Dunlap M</searchLink>; Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Badr+MS%22">Badr MS</searchLink>; Department of Medicine, School of Medicine, Wayne State University, Detroit, Michigan.<br /><searchLink fieldCode="AU" term="%22Shah+N%22">Shah N</searchLink>; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.<br /><searchLink fieldCode="AU" term="%22Chi+L%22">Chi L</searchLink>; Department of Neurology, Sleep Medicine Center, and.<br /><searchLink fieldCode="AU" term="%22Majid+R%22">Majid R</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, McGovern Medical School, UT Health, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Teodorescu+M%22">Teodorescu M</searchLink>; Department of Medicine and Wisconsin Institute for Sleep and Consciousness and.<br /><searchLink fieldCode="AU" term="%22Stewart+G%22">Stewart G</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Hsich+E%22">Hsich E</searchLink>; Department of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Polonsky+T%22">Polonsky T</searchLink>; Section of Cardiology, Department of Medicine, University of Chicago, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Vader+J%22">Vader J</searchLink>; Cardiology Division, Department of Internal Medicine, School of Medicine, Washington University, St. Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Johnson+MR%22">Johnson MR</searchLink>; Department of Medicine, Heart Failure and Transplant Cardiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.<br /><searchLink fieldCode="AU" term="%22Auckley+D%22">Auckley D</searchLink>; Department of Medicine, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio.<br /><searchLink fieldCode="AU" term="%22Yaggi+HK%22">Yaggi HK</searchLink>; Department of Medicine, Yale University, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Kao+A%22">Kao A</searchLink>; St. Luke's Mid America Heart Institute, Kansas City, Missouri.<br /><searchLink fieldCode="AU" term="%22Azarbarzin+A%22">Azarbarzin A</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Alex+R%22">Alex R</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Rueschman+M%22">Rueschman M</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wolfe+L%22">Wolfe L</searchLink>; Feinberg School of Medicine, Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Gottlieb+DJ%22">Gottlieb DJ</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Medical Service, VA Boston Healthcare System, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Sands+SA%22">Sands SA</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Zee+PC%22">Zee PC</searchLink>; Department of Neurology.<br /><searchLink fieldCode="AU" term="%22Mehra+R%22">Mehra R</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Mokhlesi+B%22">Mokhlesi B</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Khayat+R%22">Khayat R</searchLink>; Division of Pulmonary, Allergy, and Critical Care, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Lewis+EF%22">Lewis EF</searchLink>; Division of Cardiology, Department of Medicine, Stanford University, Palo Alto, California; and.<br /><searchLink fieldCode="AU" term="%22Abraham+WT%22">Abraham WT</searchLink>; Division of Cardiovascular Medicine and Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.; Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Massachusetts.
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