Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury.

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Title: Astrocytic monoamine oxidase B (MAOB)-gamma-aminobutyric acid (GABA) axis as a molecular brake on repair following spinal cord injury.
Authors: Lee HY; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Lee JM; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea., Lee HL; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Park J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., An H; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea., Park EK; NeuroBiogen Co., LTD, Seocho-gu, Seoul, Republic of Korea., Hwang SY; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Yoon SL; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Hwang GY; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Kim KN; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea., Nam MH; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; University of Science and Technology, Seoul, Republic of Korea., Lee SE; Research Animal Resources Center, Korea Institute of Science and Technology (KIST), Seoul, Korea., Kang H; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea., Won J; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea., Jang BK; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; University of Science and Technology, Seoul, Republic of Korea., Lee EH; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; University of Science and Technology, Seoul, Republic of Korea., Choi S; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea.; Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea., Park MG; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea., Kim SW; NeuroBiogen Co., LTD, Seocho-gu, Seoul, Republic of Korea., Park KD; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.; University of Science and Technology, Seoul, Republic of Korea., Lee S; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea., Lee CJ; Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea. cjl@ibs.re.kr., Ha Y; Spine & Spinal Cord Institute, Department of Neurosurgery, College of Medicine, Yonsei University, Seoul, Republic of Korea. hayoon@yuhs.ac.; POSTECH Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. hayoon@yuhs.ac.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2025 Sep 11; Vol. 10 (1), pp. 295. Date of Electronic Publication: 2025 Sep 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2059-3635
DOI:10.1038/s41392-025-02398-2