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A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia.

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Title: A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia.
Authors: Kanari M; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland., Jimenez Garcia I; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland., Steffen FD; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland., Krattiger LA; University Hospital Zurich, Department of Obstetrics, Zurich, Switzerland., Bataclan C; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland., Liu W; Laboratory of Systems Biology and Genetics, Institute of Bio-Engineering & Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland., Simona BR; ECTICA Technologies AG, Zurich, Switzerland., Deplancke B; Laboratory of Systems Biology and Genetics, Institute of Bio-Engineering & Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Naveiras O; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Hematology Service, Departments of Oncology and Laboratory Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Ehrbar M; University Hospital Zurich, Department of Obstetrics, Zurich, Switzerland., Bornhauser B; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland., Bourquin JP; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland. jean-pierre.bourquin@kispi.uzh.ch.
Source: Leukemia [Leukemia] 2025 Dec; Vol. 39 (12), pp. 2881-2894. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Kanari+M%22">Kanari M</searchLink>; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jimenez+Garcia+I%22">Jimenez Garcia I</searchLink>; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Steffen+FD%22">Steffen FD</searchLink>; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Krattiger+LA%22">Krattiger LA</searchLink>; University Hospital Zurich, Department of Obstetrics, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bataclan+C%22">Bataclan C</searchLink>; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Laboratory of Systems Biology and Genetics, Institute of Bio-Engineering & Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Simona+BR%22">Simona BR</searchLink>; ECTICA Technologies AG, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deplancke+B%22">Deplancke B</searchLink>; Laboratory of Systems Biology and Genetics, Institute of Bio-Engineering & Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Naveiras+O%22">Naveiras O</searchLink>; Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.; Hematology Service, Departments of Oncology and Laboratory Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ehrbar+M%22">Ehrbar M</searchLink>; University Hospital Zurich, Department of Obstetrics, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bornhauser+B%22">Bornhauser B</searchLink>; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bourquin+JP%22">Bourquin JP</searchLink>; University Children's Hospital Zurich, Pediatric Oncology and Children's Research Center, Zurich, Switzerland. jean-pierre.bourquin@kispi.uzh.ch.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2025 Dec; Vol. 39 (12), pp. 2881-2894. <i>Date of Electronic Publication: </i>2025 Sep 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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