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A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.

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Title: A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.
Authors: Brilland B; Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Department of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Québec, Canada. Electronic address: benoit.brilland@chu-angers.fr., Despré M; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France., Khatri R; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany., Quéméneur T; Nephrology and Internal Medicine Department, Hospital of Valenciennes, Valenciennes, France., Vandenbussche C; Nephrology and Internal Medicine Department, Hospital of Valenciennes, Valenciennes, France., Merillon N; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Laboratoire d'Immunologie et d'Allergologie, CHU d'Angers, Angers, France., Boizard-Moracchini A; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France., Roy M; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France., Preisser L; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France., Riou J; Département de Méthodologie et Biostatistiques, Délégation pour la Recherche Clinique et l'Innovation, CHU Angers, Angers, France., Piccoli GB; Service de Néphrologie-Dialyse, Centre Hospitalier du Mans, Le Mans, France., Djema A; Service de Néphrologie-Dialyse, Centre Hospitalier de Cholet, Cholet, France., Henry N; Service de Néphrologie-Dialyse, Centre Hospitalier de Laval, Laval, France., Blanchet O; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Centre de Ressources Biologiques, BB-0033-00038, CHU Angers, Angers, France., Bonn S; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Berthier CC; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Grayson P; National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA., Delneste Y; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Laboratoire d'Immunologie et d'Allergologie, CHU d'Angers, Angers, France., Gnemmi V; Service d'anatomopathologie, Centre Hospitalier Universitaire de Lille, Lille, France., Blanco P; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France; CNRS-UMR 5164, ImmunoConcept, Université de Bordeaux, Bordeaux, France., Copin MC; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Département de Pathologie Cellulaire et Tissulaire, CHU Angers, Angers, France., Langlais D; Department of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Québec, Canada., Augusto JF; Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France.
Corporate Authors: Maine-Anjou Registry Research Group
Source: Kidney international [Kidney Int] 2026 Jan; Vol. 109 (1), pp. 139-159. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis.
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  Data: <searchLink fieldCode="AU" term="%22Brilland+B%22">Brilland B</searchLink>; Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Department of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Québec, Canada. Electronic address: benoit.brilland@chu-angers.fr.<br /><searchLink fieldCode="AU" term="%22Despré+M%22">Despré M</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France.<br /><searchLink fieldCode="AU" term="%22Khatri+R%22">Khatri R</searchLink>; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Quéméneur+T%22">Quéméneur T</searchLink>; Nephrology and Internal Medicine Department, Hospital of Valenciennes, Valenciennes, France.<br /><searchLink fieldCode="AU" term="%22Vandenbussche+C%22">Vandenbussche C</searchLink>; Nephrology and Internal Medicine Department, Hospital of Valenciennes, Valenciennes, France.<br /><searchLink fieldCode="AU" term="%22Merillon+N%22">Merillon N</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Laboratoire d'Immunologie et d'Allergologie, CHU d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Boizard-Moracchini+A%22">Boizard-Moracchini A</searchLink>; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Roy+M%22">Roy M</searchLink>; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Preisser+L%22">Preisser L</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France.<br /><searchLink fieldCode="AU" term="%22Riou+J%22">Riou J</searchLink>; Département de Méthodologie et Biostatistiques, Délégation pour la Recherche Clinique et l'Innovation, CHU Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Piccoli+GB%22">Piccoli GB</searchLink>; Service de Néphrologie-Dialyse, Centre Hospitalier du Mans, Le Mans, France.<br /><searchLink fieldCode="AU" term="%22Djema+A%22">Djema A</searchLink>; Service de Néphrologie-Dialyse, Centre Hospitalier de Cholet, Cholet, France.<br /><searchLink fieldCode="AU" term="%22Henry+N%22">Henry N</searchLink>; Service de Néphrologie-Dialyse, Centre Hospitalier de Laval, Laval, France.<br /><searchLink fieldCode="AU" term="%22Blanchet+O%22">Blanchet O</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Centre de Ressources Biologiques, BB-0033-00038, CHU Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Bonn+S%22">Bonn S</searchLink>; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Medical Systems Bioinformatics, Center for Biomedical AI, Center for Molecular Neurobiology Hamburg, Hamburg, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Berthier+CC%22">Berthier CC</searchLink>; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.<br /><searchLink fieldCode="AU" term="%22Grayson+P%22">Grayson P</searchLink>; National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Delneste+Y%22">Delneste Y</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Laboratoire d'Immunologie et d'Allergologie, CHU d'Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Gnemmi+V%22">Gnemmi V</searchLink>; Service d'anatomopathologie, Centre Hospitalier Universitaire de Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Blanco+P%22">Blanco P</searchLink>; Laboratoire d'Immunologie et Immunogénétique, FHU ACRONIM, Hôpital Pellegrin, Centre Hospitalier Universitaire de Bordeaux, France; CNRS-UMR 5164, ImmunoConcept, Université de Bordeaux, Bordeaux, France.<br /><searchLink fieldCode="AU" term="%22Copin+MC%22">Copin MC</searchLink>; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France; Département de Pathologie Cellulaire et Tissulaire, CHU Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Langlais+D%22">Langlais D</searchLink>; Department of Human Genetics, Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Augusto+JF%22">Augusto JF</searchLink>; Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France; Univ Angers, Nantes Université, Inserm, CNRS, CRCI2NA, SFR ICAT, Angers, France.
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