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Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches.

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Title: Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches.
Authors: Paim MP; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Rech TDST; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Krüger LD; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Magalhães LS; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Penteado F; Center for Natural and Exact Sciences-CCNE, Federal University of Santa Maria-UFSM, Roraima Avenue, Building 18, 97105-340 Santa Maria, Rio Grande do Sul, Brazil., Gomes CS; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil., Lenardão EJ; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil., Brüning CA; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Bortolatto CF; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3713-3727. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1948-7193
DOI:10.1021/acschemneuro.5c00233