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Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches.

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Title: Antidepressant-like Properties of a Selenium-Containing Pyridinium Salt Explored through In Vitro, In Vivo, and In Silico Approaches.
Authors: Paim MP; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Rech TDST; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Krüger LD; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Magalhães LS; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Penteado F; Center for Natural and Exact Sciences-CCNE, Federal University of Santa Maria-UFSM, Roraima Avenue, Building 18, 97105-340 Santa Maria, Rio Grande do Sul, Brazil., Gomes CS; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil., Lenardão EJ; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil., Brüning CA; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil., Bortolatto CF; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
Source: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3713-3727. Date of Electronic Publication: 2025 Sep 12.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Paim+MP%22">Paim MP</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Rech+TDST%22">Rech TDST</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Krüger+LD%22">Krüger LD</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Magalhães+LS%22">Magalhães LS</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Penteado+F%22">Penteado F</searchLink>; Center for Natural and Exact Sciences-CCNE, Federal University of Santa Maria-UFSM, Roraima Avenue, Building 18, 97105-340 Santa Maria, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Gomes+CS%22">Gomes CS</searchLink>; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Lenardão+EJ%22">Lenardão EJ</searchLink>; Postgraduate Program in Chemistry (PPGQ), Clean Organic Synthesis Laboratory (LASOL), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), P.O. Box 354, 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Brüning+CA%22">Brüning CA</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.<br /><searchLink fieldCode="AU" term="%22Bortolatto+CF%22">Bortolatto CF</searchLink>; Postgraduate Program in Biochemistry and Bioprospecting, Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), 96010-900 Pelotas, Rio Grande do Sul, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101525337%22">ACS chemical neuroscience</searchLink> [ACS Chem Neurosci] 2025 Oct 01; Vol. 16 (19), pp. 3713-3727. <i>Date of Electronic Publication: </i>2025 Sep 12.
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