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Outcomes of local therapies for recurrent and radiation-associated soft tissue sarcomas of the extremities and trunk: is there a role for re-irradiation?

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Title: Outcomes of local therapies for recurrent and radiation-associated soft tissue sarcomas of the extremities and trunk: is there a role for re-irradiation?
Authors: Krcek R; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Inselspital, Department of Radiation Oncology, Bern University Hospital and University of Bern, Bern, Switzerland; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Griffin AM; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Catton CN; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Chung PWM; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., O'Sullivan B; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiology, Radio-Oncology and Nuclear Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC H2X 0C1, Canada., Parent A; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada., Roohani S; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany., Shultz DB; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Wong P; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada., Ferguson PC; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Tsoi K; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Wunder JS; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada., Kirsch DG; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address: David.Kirsch@uhn.ca.
Source: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2025 Nov; Vol. 212, pp. 111136. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Outcomes of local therapies for recurrent and radiation-associated soft tissue sarcomas of the extremities and trunk: is there a role for re-irradiation?
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  Data: <searchLink fieldCode="AU" term="%22Krcek+R%22">Krcek R</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Inselspital, Department of Radiation Oncology, Bern University Hospital and University of Bern, Bern, Switzerland; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Griffin+AM%22">Griffin AM</searchLink>; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Catton+CN%22">Catton CN</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chung+PWM%22">Chung PWM</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+B%22">O'Sullivan B</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiology, Radio-Oncology and Nuclear Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC H2X 0C1, Canada.<br /><searchLink fieldCode="AU" term="%22Parent+A%22">Parent A</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Roohani+S%22">Roohani S</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Shultz+DB%22">Shultz DB</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+P%22">Wong P</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ferguson+PC%22">Ferguson PC</searchLink>; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Tsoi+K%22">Tsoi K</searchLink>; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Wunder+JS%22">Wunder JS</searchLink>; Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Canada; Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Kirsch+DG%22">Kirsch DG</searchLink>; Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address: David.Kirsch@uhn.ca.
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        Value: 10.1016/j.radonc.2025.111136
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      – Code: eng
        Text: English
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              Text: 2025 Nov
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