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Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.

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Title: Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.
Authors: Fujita S; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan., Fuchikami M; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan. mf547@hiroshima-u.ac.jp., Fujita S; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan., Miyagi T; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan., Okada S; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan., Omura J; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan., Morinobu S; Department of Psychology, School of Faculty of Health and Wellness Sciences, Hiroshima International University, Kure, Japan.
Source: Psychopharmacology [Psychopharmacology (Berl)] 2026 Jun; Vol. 243 (6), pp. 1397-1408. Date of Electronic Publication: 2025 Sep 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.
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  Data: <searchLink fieldCode="AU" term="%22Fujita+S%22">Fujita S</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Fuchikami+M%22">Fuchikami M</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan. mf547@hiroshima-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Fujita+S%22">Fujita S</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Miyagi+T%22">Miyagi T</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+S%22">Okada S</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Omura+J%22">Omura J</searchLink>; Department of Psychiatry and Neuroscience, Division of Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-Ku, Kasumi 1-2-3, Hiroshima, Japan.<br /><searchLink fieldCode="AU" term="%22Morinobu+S%22">Morinobu S</searchLink>; Department of Psychology, School of Faculty of Health and Wellness Sciences, Hiroshima International University, Kure, Japan.
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  Data: <searchLink fieldCode="JN" term="%227608025%22">Psychopharmacology</searchLink> [Psychopharmacology (Berl)] 2026 Jun; Vol. 243 (6), pp. 1397-1408. <i>Date of Electronic Publication: </i>2025 Sep 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>7608025 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-2072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200333158%22">00333158 </searchLink><i>NLM ISO Abbreviation: </i>Psychopharmacology (Berl) <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00213-025-06891-y
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        Text: English
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      – TitleFull: Chemogenetic activation of the medial prefrontal cortex alleviates the impaired extinction of fear memory through the increase in the binding of EGR1 and TET1 in an animal model of PTSD.
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              Text: 2026 Jun
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              Y: 2026
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              Value: 243
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