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METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.

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Title: METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.
Authors: Bove G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Babaei M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Bueno-Costa A; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain., Amin S; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Simonelli N; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Benedetti R; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy., Dell'Aversana C; IEOS-CNR Institute for endocrinology and oncology 'Gaetano Salvatore', Via Sergio Pansini 5, Naples, Italy.; Department of Medicine and Surgery, LUM University, Casamassima (BA), Bari, Italy., Conte M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Montella L; Medical Oncology Complex Unit, 'Santa Maria delle Grazie' Hospital, ASL Napoli 2 Nord, Naples, Italy., Summa V; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy., Brindisi M; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy., Del Sorbo MR; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Crepaldi M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Favale G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Profitos-Peleja N; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., Carafa V; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy., Roué G; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., Ciardiello F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Capuano A; Departemnt of Sperimental Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Stunnenberg HG; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands.; Radboud University, Faculty of Science, Department of Molecular Biology, Nijmegen, The Netherlands., Megchelenbrink WL; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands., Nebbioso A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy., Esteller M; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Madrid, Spain. mesteller@carrerasresearch.org.; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org., Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. lucia.altucci@unicampania.it.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy. lucia.altucci@unicampania.it.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy. lucia.altucci@unicampania.it., Del Gaudio N; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. nunzio.delgaudio@unicampania.it.; Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale Di San Pio V 44, Rome, Italy. nunzio.delgaudio@unicampania.it.
Source: Oncogene [Oncogene] 2025 Nov; Vol. 44 (43), pp. 4159-4172. Date of Electronic Publication: 2025 Sep 14.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.
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  Data: <searchLink fieldCode="AU" term="%22Bove+G%22">Bove G</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Babaei+M%22">Babaei M</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Bueno-Costa+A%22">Bueno-Costa A</searchLink>; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Amin+S%22">Amin S</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Simonelli+N%22">Simonelli N</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Benedetti+R%22">Benedetti R</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Dell'Aversana+C%22">Dell'Aversana C</searchLink>; IEOS-CNR Institute for endocrinology and oncology 'Gaetano Salvatore', Via Sergio Pansini 5, Naples, Italy.; Department of Medicine and Surgery, LUM University, Casamassima (BA), Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Conte+M%22">Conte M</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Montella+L%22">Montella L</searchLink>; Medical Oncology Complex Unit, 'Santa Maria delle Grazie' Hospital, ASL Napoli 2 Nord, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Summa+V%22">Summa V</searchLink>; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Brindisi+M%22">Brindisi M</searchLink>; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Del+Sorbo+MR%22">Del Sorbo MR</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Crepaldi+M%22">Crepaldi M</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Favale+G%22">Favale G</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Profitos-Peleja+N%22">Profitos-Peleja N</searchLink>; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Carafa+V%22">Carafa V</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy.<br /><searchLink fieldCode="AU" term="%22Roué+G%22">Roué G</searchLink>; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Ciardiello+F%22">Ciardiello F</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Capuano+A%22">Capuano A</searchLink>; Departemnt of Sperimental Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Stunnenberg+HG%22">Stunnenberg HG</searchLink>; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands.; Radboud University, Faculty of Science, Department of Molecular Biology, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Megchelenbrink+WL%22">Megchelenbrink WL</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Nebbioso+A%22">Nebbioso A</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Esteller+M%22">Esteller M</searchLink>; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Madrid, Spain. mesteller@carrerasresearch.org.; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.<br /><searchLink fieldCode="AU" term="%22Altucci+L%22">Altucci L</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. lucia.altucci@unicampania.it.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy. lucia.altucci@unicampania.it.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy. lucia.altucci@unicampania.it.<br /><searchLink fieldCode="AU" term="%22Del+Gaudio+N%22">Del Gaudio N</searchLink>; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. nunzio.delgaudio@unicampania.it.; Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale Di San Pio V 44, Rome, Italy. nunzio.delgaudio@unicampania.it.
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