METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis.
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| Title: | METTL16-mediated inhibition of MXD4 promotes leukemia through activation of the MYC-MAX axis. |
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| Authors: | Bove G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Babaei M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Bueno-Costa A; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain., Amin S; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Simonelli N; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Benedetti R; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy., Dell'Aversana C; IEOS-CNR Institute for endocrinology and oncology 'Gaetano Salvatore', Via Sergio Pansini 5, Naples, Italy.; Department of Medicine and Surgery, LUM University, Casamassima (BA), Bari, Italy., Conte M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Montella L; Medical Oncology Complex Unit, 'Santa Maria delle Grazie' Hospital, ASL Napoli 2 Nord, Naples, Italy., Summa V; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy., Brindisi M; Department of Pharmacy, School of Medicine and Surgery, University of Naples 'Federico II', Via D. Montesano 49, Naples, Italy., Del Sorbo MR; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Crepaldi M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Favale G; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Profitos-Peleja N; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., Carafa V; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy., Roué G; Lymphoma Translational Group, Josep Carreras Leukaemia Research Institute (IJC), Badalona, Spain., Ciardiello F; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Capuano A; Departemnt of Sperimental Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy., Stunnenberg HG; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands.; Radboud University, Faculty of Science, Department of Molecular Biology, Nijmegen, The Netherlands., Megchelenbrink WL; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Prinses Máxima Centrum, Heidelberglaan 25, Utrecht, The Netherlands., Nebbioso A; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy., Esteller M; Cancer Epigenetics Group, Josep Carreras Leukaemia Research Institute (IJC), IJC Building, Germans Trias I Pujol, Ctra de Can Ruti, Cami de Les Escoles S/N, 08916 Badalona, Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Centro de Investigación Biomédica en Red Cancer (CIBERONC), Madrid, Spain. mesteller@carrerasresearch.org.; Instituciò Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org.; Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain. mesteller@carrerasresearch.org., Altucci L; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. lucia.altucci@unicampania.it.; Program of Medical Epigenetics, Vanvitelli Hospital, Naples, Italy. lucia.altucci@unicampania.it.; BIOGEM, Via Camporeale Area P.I.P., Ariano Irpino (AV), Italy. lucia.altucci@unicampania.it., Del Gaudio N; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Vico L. de Crecchio 7, Naples, Italy. nunzio.delgaudio@unicampania.it.; Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale Di San Pio V 44, Rome, Italy. nunzio.delgaudio@unicampania.it. |
| Source: | Oncogene [Oncogene] 2025 Nov; Vol. 44 (43), pp. 4159-4172. Date of Electronic Publication: 2025 Sep 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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