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The LRRK2 p.A419V variant associates with risk of Parkinson's disease in the East Asian population and an evaluation on age of onset.

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Title: The LRRK2 p.A419V variant associates with risk of Parkinson's disease in the East Asian population and an evaluation on age of onset.
Authors: Lim KS; Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Periñan MT; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Seville, Spain.; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom., Chew EGY; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Lee PS; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA., Akçimen F; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Lim JL; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Koretsky MJ; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA., Funayama M; Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; International Collaborative Research Administration, Juntendo University, Tokyo, Japan., Yoshino H; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Hattori N; Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan., Kaiyrzhanov R; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.; South Kazakhstan Medical Academy, Department of Neurology, 1/1 Al-Farabi Avenue, 160019 Shymkent, Kazakhstan., Houlden H; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Isayan M; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia., Tay YW; Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Toh TS; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Lit LC; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Khairul Anuar AN; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Ding HX; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia., Screven L; The Global Parkinson's Genetics Program (GP2)., Mohamed Ibrahim N; Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia., Lin CH; Department of Neurology, National Taiwan University Hospital Taipei, Taipei, Taiwan., Kim HJ; Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea., Lee JY; Department of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea., Chung SJ; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea., Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore., Tan EK; Duke-National University of Singapore Medical School, Singapore, Singapore; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore, Singapore., Lim SY; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Tan AH; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Bandres-Ciga S; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA., Ahmad-Annuar A; Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Corporate Authors: Global Parkinson’s Genetics Program (GP2)
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Sep 02. Date of Electronic Publication: 2025 Sep 02.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: The LRRK2 p.A419V variant associates with risk of Parkinson's disease in the East Asian population and an evaluation on age of onset.
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  Data: <searchLink fieldCode="AU" term="%22Lim+KS%22">Lim KS</searchLink>; Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Periñan+MT%22">Periñan MT</searchLink>; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Sevilla, Seville, Spain.; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chew+EGY%22">Chew EGY</searchLink>; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+PS%22">Lee PS</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Akçimen+F%22">Akçimen F</searchLink>; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lim+JL%22">Lim JL</searchLink>; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Koretsky+MJ%22">Koretsky MJ</searchLink>; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Funayama+M%22">Funayama M</searchLink>; Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.; International Collaborative Research Administration, Juntendo University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshino+H%22">Yoshino H</searchLink>; Research Institute for Diseases of Old Age, Graduate School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Hattori+N%22">Hattori N</searchLink>; Department of Neurology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.<br /><searchLink fieldCode="AU" term="%22Kaiyrzhanov+R%22">Kaiyrzhanov R</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.; South Kazakhstan Medical Academy, Department of Neurology, 1/1 Al-Farabi Avenue, 160019 Shymkent, Kazakhstan.<br /><searchLink fieldCode="AU" term="%22Houlden+H%22">Houlden H</searchLink>; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Isayan+M%22">Isayan M</searchLink>; Department of Neurology and Neurosurgery, National Institute of Health, Yerevan, Armenia.<br /><searchLink fieldCode="AU" term="%22Tay+YW%22">Tay YW</searchLink>; Department of Biomedical Science, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Toh+TS%22">Toh TS</searchLink>; Department of Medicine, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.; The Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lit+LC%22">Lit LC</searchLink>; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Khairul+Anuar+AN%22">Khairul Anuar AN</searchLink>; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ding+HX%22">Ding HX</searchLink>; Department of Physiology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.<br /><searchLink fieldCode="AU" term="%22Screven+L%22">Screven L</searchLink>; The Global Parkinson's Genetics Program (GP2).<br /><searchLink fieldCode="AU" term="%22Mohamed+Ibrahim+N%22">Mohamed Ibrahim N</searchLink>; Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Neurology, National Taiwan University Hospital Taipei, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Kim+HJ%22">Kim HJ</searchLink>; Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; Department of Neurology, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.<br /><searchLink fieldCode="AU" term="%22Chung+SJ%22">Chung SJ</searchLink>; Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.<br /><searchLink fieldCode="AU" term="%22Foo+JN%22">Foo JN</searchLink>; 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