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Programming Aptamer-Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure.

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Title: Programming Aptamer-Protein Complexation Kinetics via Modulation of G-Quadruplex Secondary Structure.
Authors: Flynn CD; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States.; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States., Chang D; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States.; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, United States., Lee Y; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States., Isaacson SE; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States., Wu Z; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States., Rivnay J; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States., Kelley SO; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States.; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States.; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Biochemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, United States.; International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.; Simpson Querrey Institute, Northwestern University, Chicago, Illinois 60611, United States.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2025 Sep 24; Vol. 147 (38), pp. 34204-34210. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Flynn+CD%22">Flynn CD</searchLink>; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States.; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States.<br /><searchLink fieldCode="AU" term="%22Chang+D%22">Chang D</searchLink>; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States.; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Isaacson+SE%22">Isaacson SE</searchLink>; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Rivnay+J%22">Rivnay J</searchLink>; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.<br /><searchLink fieldCode="AU" term="%22Kelley+SO%22">Kelley SO</searchLink>; Department of Chemistry, Weinberg College of Arts & Sciences, Northwestern University, Evanston, Illinois 60208, United States.; Chan Zuckerberg Biohub Chicago, Chicago, Illinois 60642, United States.; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.; Department of Biochemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, United States.; International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States.; Simpson Querrey Institute, Northwestern University, Chicago, Illinois 60611, United States.
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        Value: 10.1021/jacs.5c10067
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