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Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.

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Title: Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.
Authors: Salvadó G; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Barcelonaßeta Brain Research Center, Barcelona, Spain., Janelidze S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Bali D; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Dolado AO; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Therriault J; Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, The McGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Brum WS; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Pichet Binette A; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Stomrud E; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Mattsson-Carlgren N; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.; Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden., Palmqvist S; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden., Coomans EM; Alzheimer Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands., Teunissen CE; Neurochemistry Laboratory, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands., van der Flier WM; Alzheimer Center Amsterdam, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, the Netherlands., Rahmouni N; Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, The McGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Benzinger TLS; Washington University School of Medicine in St Louis, St Louis, Missouri.; Knight Alzheimer Disease Research Center, St Louis, Missouri., Gispert JD; Barcelonaßeta Brain Research Center, Barcelona, Spain.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain.; Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain., Blennow K; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.; Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.; Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of the University of Science and Technology of China, Hefei, People's Republic of China., Doré V; Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Victoria, Australia.; The Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Melbourne, Victoria, Australia., Feizpour A; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Rowe CC; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Victoria, Australia.; Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia., Alcolea D; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigació Biomèdica Sant Pau, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain., Fortea J; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigació Biomèdica Sant Pau, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain., Villeneuve S; Centre for Studies on Prevention of Alzheimer's Disease, Douglas Mental Health Institute, Montreal, Quebec, Canada.; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison., Rosa-Neto P; Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, The McGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Centre for Studies on Prevention of Alzheimer's Disease, Montreal, Quebec, Canada., Petersen RC; Department of Neurology, Mayo Clinic, Rochester, Minnesota., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Schindler SE; Washington University School of Medicine in St Louis, St Louis, Missouri.; Knight Alzheimer Disease Research Center, St Louis, Missouri., Suárez-Calvet M; Barcelonaßeta Brain Research Center, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain.; Servei de Neurologia, Hospital del Mar, Barcelona, Spain., Ossenkoppele R; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Alzheimer Center Amsterdam, Neurology, Amsterdam University Medical Center, Amsterdam, the Netherlands., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Corporate Authors: ADNI, ALFA, and PREVENT-AD Study Groups
Source: JAMA neurology [JAMA Neurol] 2025 Nov 01; Vol. 82 (11), pp. 1122-1134.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma Phosphorylated Tau 217 to Identify Preclinical Alzheimer Disease.
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  Data: <searchLink fieldCode="AU" term="%22Salvadó+G%22">Salvadó G</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.; Barcelonaßeta Brain Research Center, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Janelidze+S%22">Janelidze S</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Bali+D%22">Bali D</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Dolado+AO%22">Dolado AO</searchLink>; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Therriault+J%22">Therriault J</searchLink>; Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, The McGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.; 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Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands.; Epidemiology and Data Science, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, The McGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Washington University School of Medicine in St Louis, St Louis, Missouri.; Knight Alzheimer Disease Research Center, St Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Gispert+JD%22">Gispert JD</searchLink>; Barcelonaßeta Brain Research Center, Barcelona, Spain.; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; 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Sant Pau Memory Unit, Department of Neurology, Institut d'Investigació Biomèdica Sant Pau, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fortea+J%22">Fortea J</searchLink>; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigació Biomèdica Sant Pau, Hospital de La Santa Creu I Sant Pau, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Madrid, Spain.; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Villeneuve+S%22">Villeneuve S</searchLink>; Centre for Studies on Prevention of Alzheimer's Disease, Douglas Mental Health Institute, Montreal, Quebec, Canada.; Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Johnson+SC%22">Johnson SC</searchLink>; 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