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Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma.

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Title: Screening FDA-Approved Oncology Drugs with Three-Dimensional Spheroids Identifies Romidepsin as a Therapeutic Candidate for Osteosarcoma.
Authors: Seiden EE; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana., Richardson SM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana., Everitt LA; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Knafler GJ; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Walker AL; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Whiteside VA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Pillutla D; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Ramnath S; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Kinsella GP; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana., Wilburn PA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana., Buschbach JD; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Gandhi DA; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Saadatzadeh MR; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana., Wurtz LD; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana., Getty PJ; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Padgett SL; Metropolitan Veterinary Hospital, Akron, Ohio., Gamblin RM; Metropolitan Veterinary Hospital, Akron, Ohio., Childress MO; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana.; College of Veterinary Medicine, Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Evan and Sue Ann Werling Comparative Oncology Research Center, Purdue University, West Lafayette, Indiana., Fulkerson CM; Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana.; College of Veterinary Medicine, Purdue Institute for Cancer Research, Purdue University, West Lafayette, Indiana.; Evan and Sue Ann Werling Comparative Oncology Research Center, Purdue University, West Lafayette, Indiana., Capitano ML; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana., Pollok KE; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana., Collier CD; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio., Greenfield EM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana.; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, Indiana.; Department of Orthopaedics, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.
Source: Cancer research communications [Cancer Res Commun] 2025 Oct 01; Vol. 5 (10), pp. 1821-1838.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9918281580506676 Publication Model: Print Cited Medium: Internet ISSN: 2767-9764 (Electronic) Linking ISSN: 27679764 NLM ISO Abbreviation: Cancer Res Commun Subsets: MEDLINE
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