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Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma.

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Title: Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma.
Authors: Yan Z; Department of Pathology, Duke University School of Medicine, Durham, NC.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC., Han Z; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC., Wang Y; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC., Beus M; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC., Zhang Y; Department of Hematology and Medical Oncology, Emory School of Medicine and the Winship Cancer Institute, Emory University, Atlanta, GA., Picado A; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC., Wu J; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC., Weidenhammer LB; Department of Pathology, Duke University School of Medicine, Durham, NC., Pires KM; Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, The University of Utah, Salt Lake City, UT., Leibold EA; Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, The University of Utah, Salt Lake City, UT., Liu L; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC., Gooden DM; Small Molecule Synthesis Facility, Department of Chemistry, Duke University, Durham, NC., Spasojevic I; Pharmacokinetics and Pharmacodynamics Core, Duke Cancer Institute, and Department of Medicine, Duke University Medical Center, Durham, NC., Soderblom EJ; Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC., Kang Y; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC., Boise LH; Department of Hematology and Medical Oncology, Emory School of Medicine and the Winship Cancer Institute, Emory University, Atlanta, GA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC., Nikiforov MA; Department of Pathology, Duke University School of Medicine, Durham, NC.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.
Source: Blood [Blood] 2026 Jan 01; Vol. 147 (1), pp. 48-60.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Yan+Z%22">Yan Z</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Han+Z%22">Han Z</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Beus+M%22">Beus M</searchLink>; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Hematology and Medical Oncology, Emory School of Medicine and the Winship Cancer Institute, Emory University, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Picado+A%22">Picado A</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Wells+CI%22">Wells CI</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Weidenhammer+LB%22">Weidenhammer LB</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Pires+KM%22">Pires KM</searchLink>; Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, The University of Utah, Salt Lake City, UT.<br /><searchLink fieldCode="AU" term="%22Leibold+EA%22">Leibold EA</searchLink>; Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, The University of Utah, Salt Lake City, UT.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC.<br /><searchLink fieldCode="AU" term="%22Gooden+DM%22">Gooden DM</searchLink>; Small Molecule Synthesis Facility, Department of Chemistry, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Spasojevic+I%22">Spasojevic I</searchLink>; Pharmacokinetics and Pharmacodynamics Core, Duke Cancer Institute, and Department of Medicine, Duke University Medical Center, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Soderblom+EJ%22">Soderblom EJ</searchLink>; Proteomics and Metabolomics Core Facility, Duke University School of Medicine, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Kang+Y%22">Kang Y</searchLink>; Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Boise+LH%22">Boise LH</searchLink>; Department of Hematology and Medical Oncology, Emory School of Medicine and the Winship Cancer Institute, Emory University, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Willson+TM%22">Willson TM</searchLink>; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.<br /><searchLink fieldCode="AU" term="%22Nikiforov+MA%22">Nikiforov MA</searchLink>; Department of Pathology, Duke University School of Medicine, Durham, NC.; Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC.
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        Value: 10.1182/blood.2025029950
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              Text: 2026 Jan 01
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