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The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.

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Title: The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.
Authors: Chan LP; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Tseng YP; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan., Wang HC; Department of Internal Medicine, Division of Hematology and Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Chien CY; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Municipal Siaogang Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Wu CW; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Wang LF; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Yen TW; Department of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan., Wang PC; Department of Food and Drug Industry and Inspective Technology, Chia nan University of Pharmacy and Science, Tainan, Taiwan., Liaw CC; Department of Marine Biotechnology and Resources, National sun Yat-Sen University, Kaohsiung, Taiwan.; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan., Liang CH; Department of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan.
Source: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2026 Jan; Vol. 55 (1), pp. 61-72. Date of Electronic Publication: 2025 Sep 15.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8911934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0714 (Electronic) Linking ISSN: 09042512 NLM ISO Abbreviation: J Oral Pathol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.
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  Data: <searchLink fieldCode="AU" term="%22Chan+LP%22">Chan LP</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tseng+YP%22">Tseng YP</searchLink>; Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+HC%22">Wang HC</searchLink>; Department of Internal Medicine, Division of Hematology and Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+CY%22">Chien CY</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Municipal Siaogang Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CW%22">Wu CW</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+LF%22">Wang LF</searchLink>; Department of Otorhinolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+TW%22">Yen TW</searchLink>; Department of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+PC%22">Wang PC</searchLink>; Department of Food and Drug Industry and Inspective Technology, Chia nan University of Pharmacy and Science, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liaw+CC%22">Liaw CC</searchLink>; Department of Marine Biotechnology and Resources, National sun Yat-Sen University, Kaohsiung, Taiwan.; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+CH%22">Liang CH</searchLink>; Department of Cosmetic Science and Institute of Cosmetic Science, Chia nan University of Pharmacy and Science, Tainan, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%228911934%22">Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology</searchLink> [J Oral Pathol Med] 2026 Jan; Vol. 55 (1), pp. 61-72. <i>Date of Electronic Publication: </i>2025 Sep 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>Denmark <i>NLM ID: </i>8911934 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0714 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209042512%22">09042512 </searchLink><i>NLM ISO Abbreviation: </i>J Oral Pathol Med <i>Subsets: </i>MEDLINE
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        Value: 10.1111/jop.70060
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      – TitleFull: The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways.
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              Text: 2026 Jan
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