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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1.

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Title: Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1.
Authors: Fallone L; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Pouxvielh K; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Arbez L; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Rousseaux N; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Picq L; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Institut Roche, F-92100, Boulogne-Billancourt, France., Drouillard A; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Mathieu AL; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Nombel A; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Benezech S; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Bourdonnay E; CIRI, Centre International de Recherche en Infectiologie, (Team I2BA), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Degouve S; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Machy P; Nantes Université, CNRS, Inserm, CRCI2NA, F-44000, Nantes, France., Mortier E; Nantes Université, CNRS, Inserm, CRCI2NA, F-44000, Nantes, France., Bouscasse E; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France., Chaoui K; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France., Malissen B; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, F-13009, Marseille, France.; CIPHE, Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, F-13009, Marseille, France., Gonzalez de Peredo A; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France., Roncagalli R; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, F-13009, Marseille, France., Walzer T; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France., Marçais A; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
Source: Science signaling [Sci Signal] 2025 Sep 16; Vol. 18 (904), pp. eadq8778. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
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  Data: Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1.
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  Data: <searchLink fieldCode="AU" term="%22Fallone+L%22">Fallone L</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Pouxvielh+K%22">Pouxvielh K</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Arbez+L%22">Arbez L</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Rousseaux+N%22">Rousseaux N</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Picq+L%22">Picq L</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.; Institut Roche, F-92100, Boulogne-Billancourt, France.<br /><searchLink fieldCode="AU" term="%22Drouillard+A%22">Drouillard A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Mathieu+AL%22">Mathieu AL</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Nombel+A%22">Nombel A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Benezech+S%22">Benezech S</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Bourdonnay+E%22">Bourdonnay E</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team I2BA), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Degouve+S%22">Degouve S</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Machy+P%22">Machy P</searchLink>; Nantes Université, CNRS, Inserm, CRCI2NA, F-44000, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Mortier+E%22">Mortier E</searchLink>; Nantes Université, CNRS, Inserm, CRCI2NA, F-44000, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Bouscasse+E%22">Bouscasse E</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Chaoui+K%22">Chaoui K</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Malissen+B%22">Malissen B</searchLink>; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, F-13009, Marseille, France.; CIPHE, Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS UMR, F-13009, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Gonzalez+de+Peredo+A%22">Gonzalez de Peredo A</searchLink>; Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III-Paul Sabatier (UPS), F-31400, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Roncagalli+R%22">Roncagalli R</searchLink>; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, F-13009, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Walzer+T%22">Walzer T</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Marçais+A%22">Marçais A</searchLink>; CIRI, Centre International de Recherche en Infectiologie, (Team Lyacts), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2025 Sep 16; Vol. 18 (904), pp. eadq8778. <i>Date of Electronic Publication: </i>2025 Sep 16.
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