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Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.

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Title: Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
Authors: Luo X; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Zhang L; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Sakamuru S; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Adesina PA; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Zhao J; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Xia M; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Xu T; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Ngan DK; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Travers J; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Wood S; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Sukhawanit R; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Garrison A; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Klumpp-Thomas C; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Ferguson SS; Division of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA., Zhu H; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Hall MD; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA., Reif DM; Division of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA., Huang R; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA. Electronic address: huangru@mail.nih.gov.
Source: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2025 Dec; Vol. 505, pp. 117567. Date of Electronic Publication: 2025 Sep 14.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Sakamuru+S%22">Sakamuru S</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Adesina+PA%22">Adesina PA</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Xia+M%22">Xia M</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Xu+T%22">Xu T</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Ngan+DK%22">Ngan DK</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Travers+J%22">Travers J</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Wood+S%22">Wood S</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Sukhawanit+R%22">Sukhawanit R</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Garrison+A%22">Garrison A</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Klumpp-Thomas+C%22">Klumpp-Thomas C</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Ferguson+SS%22">Ferguson SS</searchLink>; Division of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+H%22">Zhu H</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Hall+MD%22">Hall MD</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA.<br /><searchLink fieldCode="AU" term="%22Reif+DM%22">Reif DM</searchLink>; Division of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC, USA.<br /><searchLink fieldCode="AU" term="%22Huang+R%22">Huang R</searchLink>; Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD 20850, USA. Electronic address: huangru@mail.nih.gov.
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  Data: <searchLink fieldCode="JN" term="%220416575%22">Toxicology and applied pharmacology</searchLink> [Toxicol Appl Pharmacol] 2025 Dec; Vol. 505, pp. 117567. <i>Date of Electronic Publication: </i>2025 Sep 14.
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        Value: 10.1016/j.taap.2025.117567
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              Text: 2025 Dec
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