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An engineered IgM antibody targeting CD20 has enhanced complement-dependent cytotoxicity compared with an IgG.

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Title: An engineered IgM antibody targeting CD20 has enhanced complement-dependent cytotoxicity compared with an IgG.
Authors: Hart KC; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA. Electronic address: hartkk16@gmail.com., Hinton PR; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Manlusoc M; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Carlin KB; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Schneider S; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Kotturi MF; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Baliga R; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA., Keyt BA; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.
Source: Experimental hematology [Exp Hematol] 2025 Dec; Vol. 152, pp. 105250. Date of Electronic Publication: 2025 Sep 14.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2399 (Electronic) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: An engineered IgM antibody targeting CD20 has enhanced complement-dependent cytotoxicity compared with an IgG.
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  Data: <searchLink fieldCode="AU" term="%22Hart+KC%22">Hart KC</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA. Electronic address: hartkk16@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hinton+PR%22">Hinton PR</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Manlusoc+M%22">Manlusoc M</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Carlin+KB%22">Carlin KB</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Schneider+S%22">Schneider S</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Kotturi+MF%22">Kotturi MF</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Baliga+R%22">Baliga R</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.<br /><searchLink fieldCode="AU" term="%22Keyt+BA%22">Keyt BA</searchLink>; IGM Biosciences Inc., 325 E Middlefield Rd., Mountain View, CA.
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  Data: <searchLink fieldCode="JN" term="%220402313%22">Experimental hematology</searchLink> [Exp Hematol] 2025 Dec; Vol. 152, pp. 105250. <i>Date of Electronic Publication: </i>2025 Sep 14.
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  Data: Journal Article; Comparative Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Inc%22">Elsevier Science Inc </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0402313 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2399 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220301472X%22">0301472X </searchLink><i>NLM ISO Abbreviation: </i>Exp Hematol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.exphem.2025.105250
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      – Code: eng
        Text: English
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      – TitleFull: An engineered IgM antibody targeting CD20 has enhanced complement-dependent cytotoxicity compared with an IgG.
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            NameFull: Hart KC
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              Text: 2025 Dec
              Type: published
              Y: 2025
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              Value: 1873-2399
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              Value: 152
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            – TitleFull: Experimental hematology
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