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A Microfluidics-Based Ultrahigh-Throughput Screening Unveils Diverse Ketoreductases Relevant to Pharmaceutical Synthesis.

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Title: A Microfluidics-Based Ultrahigh-Throughput Screening Unveils Diverse Ketoreductases Relevant to Pharmaceutical Synthesis.
Authors: Blas-Muñoz L; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain., Orrego AH; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain., Hofmeister M; Technische Universität Darmstadt, Institute of Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, Darmstadt 64287, Germany., Martínez-Salvador J; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain., Ortega C; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain., Rondón Berrio V; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain., Díaz-Rullo J; Centro de Astrobiología, (CSIC-INTA), Ctra de Torrejón a Ajalvir, km 4, Torrejón de Ardoz 28850, Spain., Finnigan J; Prozomix Ltd., Building 4, West End Ind. Estate, Haltwhistle, Northumberland NE49 9HA, United Kingdom., Charnock S; Prozomix Ltd., Building 4, West End Ind. Estate, Haltwhistle, Northumberland NE49 9HA, United Kingdom., Fessner WD; Technische Universität Darmstadt, Institute of Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, Darmstadt 64287, Germany., González-Pastor JE; Centro de Astrobiología, (CSIC-INTA), Ctra de Torrejón a Ajalvir, km 4, Torrejón de Ardoz 28850, Spain., Hidalgo A; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.; Instituto de Biología Molecular Universidad Autónoma de Madrid, Nicolás Cabrera 1, Madrid 28049, Spain.
Source: Analytical chemistry [Anal Chem] 2025 Sep 30; Vol. 97 (38), pp. 20698-20706. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Blas-Muñoz+L%22">Blas-Muñoz L</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.<br /><searchLink fieldCode="AU" term="%22Orrego+AH%22">Orrego AH</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.<br /><searchLink fieldCode="AU" term="%22Hofmeister+M%22">Hofmeister M</searchLink>; Technische Universität Darmstadt, Institute of Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, Darmstadt 64287, Germany.<br /><searchLink fieldCode="AU" term="%22Martínez-Salvador+J%22">Martínez-Salvador J</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.<br /><searchLink fieldCode="AU" term="%22Ortega+C%22">Ortega C</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.<br /><searchLink fieldCode="AU" term="%22Rondón+Berrio+V%22">Rondón Berrio V</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz-Rullo+J%22">Díaz-Rullo J</searchLink>; Centro de Astrobiología, (CSIC-INTA), Ctra de Torrejón a Ajalvir, km 4, Torrejón de Ardoz 28850, Spain.<br /><searchLink fieldCode="AU" term="%22Finnigan+J%22">Finnigan J</searchLink>; Prozomix Ltd., Building 4, West End Ind. Estate, Haltwhistle, Northumberland NE49 9HA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Charnock+S%22">Charnock S</searchLink>; Prozomix Ltd., Building 4, West End Ind. Estate, Haltwhistle, Northumberland NE49 9HA, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fessner+WD%22">Fessner WD</searchLink>; Technische Universität Darmstadt, Institute of Organic Chemistry and Biochemistry, Alarich-Weiss-Str. 4, Darmstadt 64287, Germany.<br /><searchLink fieldCode="AU" term="%22González-Pastor+JE%22">González-Pastor JE</searchLink>; Centro de Astrobiología, (CSIC-INTA), Ctra de Torrejón a Ajalvir, km 4, Torrejón de Ardoz 28850, Spain.<br /><searchLink fieldCode="AU" term="%22Hidalgo+A%22">Hidalgo A</searchLink>; Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid-Consejo Superior de Investigaciones Científicas (UAM-CSIC), Nicolás Cabrera 1, Madrid 28049, Spain.; Department of Molecular Biology, Universidad Autónoma de Madrid, Campus de Cantoblanco, Madrid 28049, Spain.; Instituto de Biología Molecular Universidad Autónoma de Madrid, Nicolás Cabrera 1, Madrid 28049, Spain.
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