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Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.

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Title: Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
Authors: Liu YX; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China., Huang H; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China., Wang F; Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China., Zhao MF; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China., Jin JY; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China., Dong Y; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China., Wang Q; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China., Fan LL; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China., Xiang R; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.; Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Source: International journal of biological sciences [Int J Biol Sci] 2025 Aug 11; Vol. 21 (12), pp. 5185-5205. Date of Electronic Publication: 2025 Aug 11 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
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  Data: Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway.
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  Data: <searchLink fieldCode="AU" term="%22Liu+YX%22">Liu YX</searchLink>; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.<br /><searchLink fieldCode="AU" term="%22Zhao+MF%22">Zhao MF</searchLink>; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Jin+JY%22">Jin JY</searchLink>; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Fan+LL%22">Fan LL</searchLink>; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.<br /><searchLink fieldCode="AU" term="%22Xiang+R%22">Xiang R</searchLink>; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, 410013, China.; Department of cell biology, School of Life Sciences, Central South University, Changsha, 410013, China.; Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410013, China.; Department of Endocrinology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2025 Aug 11; Vol. 21 (12), pp. 5185-5205. <i>Date of Electronic Publication: </i>2025 Aug 11 (<i>Print Publication: </i>2025).
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