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Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort.

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Title: Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort.
Authors: Wu S; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China., Li J; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China., Zhao X; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China., Li J; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China., Chen S; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; Ministry of Education Key Laboratory of Public Health Safety, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China., Zhang C; High School Affiliated to University of Shanghai for Science and Technology, Shanghai, 200093, China., Suo C; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; Ministry of Education Key Laboratory of Public Health Safety, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China., Wang Y; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China., Chen X; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; State Key Laboratory of Genetics and Development of Complex Phenotypes, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200433, China.; Yiwu Research Institute of Fudan University, Yiwu, 322000, Zhejiang, China., Cui M; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China. cuimei@fudan.edu.cn., Man Q; Department of Laboratory Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, 1279 Sanmen Rd, Shanghai, 200434, China. manqiuhong307@163.com., Jiang Y; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China. yanfengjiang@fudan.edu.cn.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China. yanfengjiang@fudan.edu.cn.
Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4085-4097. Date of Electronic Publication: 2025 Sep 17.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Chen+S%22">Chen S</searchLink>; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; Ministry of Education Key Laboratory of Public Health Safety, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; High School Affiliated to University of Shanghai for Science and Technology, Shanghai, 200093, China.<br /><searchLink fieldCode="AU" term="%22Suo+C%22">Suo C</searchLink>; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; Ministry of Education Key Laboratory of Public Health Safety, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China.; State Key Laboratory of Genetics and Development of Complex Phenotypes, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200433, China.; Yiwu Research Institute of Fudan University, Yiwu, 322000, Zhejiang, China.<br /><searchLink fieldCode="AU" term="%22Cui+M%22">Cui M</searchLink>; Department of Neurology, Huashan Hospital, Fudan University, No. 12 Middle Wulumuqi Road, Shanghai, 200040, China. cuimei@fudan.edu.cn.<br /><searchLink fieldCode="AU" term="%22Man+Q%22">Man Q</searchLink>; Department of Laboratory Medicine, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, 1279 Sanmen Rd, Shanghai, 200434, China. manqiuhong307@163.com.<br /><searchLink fieldCode="AU" term="%22Jiang+Y%22">Jiang Y</searchLink>; Human Phenome Institute, Research and Innovation Center, Shanghai Pudong Hospital, Zhangjiang Fudan International Innovation Center, Fudan University, 2005 Songhu Rd, Shanghai, 200433, China. yanfengjiang@fudan.edu.cn.; Fudan University Taizhou Institute of Health Sciences, Taizhou, 225326, Jiangsu, China. yanfengjiang@fudan.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4085-4097. <i>Date of Electronic Publication: </i>2025 Sep 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11357-025-01891-4
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        Text: English
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        StartPage: 4085
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              Text: 2026 Jun
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