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Identification of a broad and potent V3 glycan site bNAb targeting an N332gp120 glycan-independent epitope.

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Title: Identification of a broad and potent V3 glycan site bNAb targeting an N332gp120 glycan-independent epitope.
Authors: Gieselmann L; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, 50931 Cologne, Germany., DeLaitsch AT; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Rohde M; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Radford C; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, 98109, USA., Worczinski J; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Momot A; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Ahmadov E; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Burger JA; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands., Havenar-Daughton C; Vir Biotechnology, San Francisco, CA, USA., Deshpande S; Vir Biotechnology, San Francisco, CA, USA., Giovannoni F; Vir Biotechnology, San Francisco, CA, USA., Corti D; Vir Biotechnology, San Francisco, CA, USA., Kreer C; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Ercanoglu MS; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Schommers P; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.; Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany., Georgiev IS; Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN, USA., West AP Jr; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Knüfer J; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Stumpf R; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Kroidl A; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany., Geldmacher C; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany., Maganga L; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., William W; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., Ntinginya NE; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania., Hoelscher M; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany., Yang Z; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Wei Q; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL., Renfrow M; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Green TJ; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL., Novak J; Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands., Gristick HB; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Gruell H; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, 98109, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Bjorkman PJ; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA., Klein F; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 10. Date of Electronic Publication: 2025 Sep 10.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Identification of a broad and potent V3 glycan site bNAb targeting an N332<subscript>gp120</subscript> glycan-independent epitope.
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  Data: <searchLink fieldCode="AU" term="%22Gieselmann+L%22">Gieselmann L</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research, Partner Site Bonn-Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22DeLaitsch+AT%22">DeLaitsch AT</searchLink>; Divison of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rohde+M%22">Rohde M</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Radford+C%22">Radford C</searchLink>; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, 98109, USA.<br /><searchLink fieldCode="AU" term="%22Worczinski+J%22">Worczinski J</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Momot+A%22">Momot A</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Ahmadov+E%22">Ahmadov E</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Burger+JA%22">Burger JA</searchLink>; Department of Medical Microbiology and Infection Prevention, Laboratory of Experimental Virology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Institute for Immunology and Infectious diseases, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Havenar-Daughton+C%22">Havenar-Daughton C</searchLink>; 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Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Stumpf+R%22">Stumpf R</searchLink>; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Kroidl+A%22">Kroidl A</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Geldmacher+C%22">Geldmacher C</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Maganga+L%22">Maganga L</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22William+W%22">William W</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22Ntinginya+NE%22">Ntinginya NE</searchLink>; Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania.<br /><searchLink fieldCode="AU" term="%22Hoelscher+M%22">Hoelscher M</searchLink>; Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Germany.; German Center for Infection Research (DZIF), Partner Site, Munich, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany.; Unit Global Health, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; 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