The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS.
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| Title: | The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS. |
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| Authors: | Streltsov VA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia., Ganio KE; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia., Nuttall SD; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia., Hernandez JA; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827., Dennys CN; Nationwide Children's Hospital, Columbus, OH 43205., Crouch PJ; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia.; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827.; Nationwide Children's Hospital, Columbus, OH 43205.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3010, Australia.; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA., Estevez AG; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA., Franco MC; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA., Beckman JS; Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA., Roberts BR; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Sep 10. Date of Electronic Publication: 2025 Sep 10. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40964393 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Streltsov+VA%22">Streltsov VA</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Ganio+KE%22">Ganio KE</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Nuttall+SD%22">Nuttall SD</searchLink>; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Hernandez+JA%22">Hernandez JA</searchLink>; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827.<br /><searchLink fieldCode="AU" term="%22Dennys+CN%22">Dennys CN</searchLink>; Nationwide Children's Hospital, Columbus, OH 43205.<br /><searchLink fieldCode="AU" term="%22Crouch+PJ%22">Crouch PJ</searchLink>; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.; CSIRO Manufacturing Division, 343 Royal Parade, Parkville, Victoria, 3052, Australia.; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32827.; Nationwide Children's Hospital, Columbus, OH 43205.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3010, Australia.; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA.; Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.<br /><searchLink fieldCode="AU" term="%22Estevez+AG%22">Estevez AG</searchLink>; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA.<br /><searchLink fieldCode="AU" term="%22Franco+MC%22">Franco MC</searchLink>; Departement of Cellular & Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Port St. Lucie, Florida 34987, USA.<br /><searchLink fieldCode="AU" term="%22Beckman+JS%22">Beckman JS</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+BR%22">Roberts BR</searchLink>; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Sep 10. <i>Date of Electronic Publication: </i>2025 Sep 10. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40964393 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/2025.09.10.675162 Languages: – Code: eng Text: English Titles: – TitleFull: The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Streltsov VA – PersonEntity: Name: NameFull: Ganio KE – PersonEntity: Name: NameFull: Nuttall SD – PersonEntity: Name: NameFull: Hernandez JA – PersonEntity: Name: NameFull: Dennys CN – PersonEntity: Name: NameFull: Crouch PJ – PersonEntity: Name: NameFull: Estevez AG – PersonEntity: Name: NameFull: Franco MC – PersonEntity: Name: NameFull: Beckman JS – PersonEntity: Name: NameFull: Roberts BR IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 09 Text: 2025 Sep 10 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2692-8205 Titles: – TitleFull: BioRxiv : the preprint server for biology Type: main |
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