KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer.

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Title: KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer.
Authors: Wei Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Liu M; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Yen EY; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas., Yao J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Xun Z; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Nguyen PT; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas., Wang X; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Yang Z; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Yousef A; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Pan D; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jin Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Li CF; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Theardy MS; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Park J; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Cai Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas., Takeda M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Vasquez M; Systems Medicine and Bioengineering Department, Houston Methodist Cancer Center, Houston, Texas., Park EM; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Peng DH; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhou Y; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas., Zhao H; Systems Medicine and Bioengineering Department, Houston Methodist Cancer Center, Houston, Texas., Heffernan TP; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas., Wang H; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Watowich SS; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Liang H; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhao D; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., DePinho RA; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Yao W; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ying H; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.
Source: Cancer research [Cancer Res] 2025 Dec 01; Vol. 85 (23), pp. 4825-4838.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yen+EY%22">Yen EY</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Xun+Z%22">Xun Z</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Nguyen+PT%22">Nguyen PT</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yang+Z%22">Yang Z</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yousef+A%22">Yousef A</searchLink>; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Pan+D%22">Pan D</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Jin+Y%22">Jin Y</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Li+CF%22">Li CF</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Theardy+MS%22">Theardy MS</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Cai+Y%22">Cai Y</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Takeda+M%22">Takeda M</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Vasquez+M%22">Vasquez M</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Park+EM%22">Park EM</searchLink>; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Peng+DH%22">Peng DH</searchLink>; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Systems Medicine and Bioengineering Department, Houston Methodist Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Heffernan+TP%22">Heffernan TP</searchLink>; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Viale+A%22">Viale A</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Watowich+SS%22">Watowich SS</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22DePinho+RA%22">DePinho RA</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Yao+W%22">Yao W</searchLink>; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Ying+H%22">Ying H</searchLink>; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas.
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