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The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations.

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Title: The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations.
Authors: Hagemeier B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ripkens K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Schulze N; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Bluemke A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Strzala M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany; Research Institute of Molecular Pathology, Hasselbach Group, Vienna, Austria., Koci M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Kaschani F; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Kaiser M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Erkelenz M; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany., Schluecker S; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany., Merdanovic M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Poepsel S; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Germany., Hellerschmied D; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Burston SG; School of Biochemistry, University of Bristol, Bristol, United Kingdom., Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. Electronic address: michael.ehrmann@uni-due.de.
Source: The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110729. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations.
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  Data: <searchLink fieldCode="AU" term="%22Hagemeier+B%22">Hagemeier B</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Ripkens+K%22">Ripkens K</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+N%22">Schulze N</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Bluemke+A%22">Bluemke A</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Strzala+M%22">Strzala M</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany; Research Institute of Molecular Pathology, Hasselbach Group, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Koci+M%22">Koci M</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kaschani+F%22">Kaschani F</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kaiser+M%22">Kaiser M</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Erkelenz+M%22">Erkelenz M</searchLink>; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Schluecker+S%22">Schluecker S</searchLink>; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Merdanovic+M%22">Merdanovic M</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Poepsel+S%22">Poepsel S</searchLink>; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Hellerschmied+D%22">Hellerschmied D</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Burston+SG%22">Burston SG</searchLink>; School of Biochemistry, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ehrmann+M%22">Ehrmann M</searchLink>; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. Electronic address: michael.ehrmann@uni-due.de.
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  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110729. <i>Date of Electronic Publication: </i>2025 Sep 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbc.2025.110729
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              Text: 2025 Oct
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