The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations. - Hagemeier B; Ripkens K; Schulze N; Bluemke A; Strzala M; Koci M; Kaschani F; Kaiser M; Erkelenz M; Schluecker S; Merdanovic M; Poepsel S; et al. (The Journal of biological chemistry, 2025)