The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations.
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| Title: | The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations. |
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| Authors: | Hagemeier B; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Ripkens K; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Schulze N; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Bluemke A; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Strzala M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany; Research Institute of Molecular Pathology, Hasselbach Group, Vienna, Austria., Koci M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Kaschani F; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Kaiser M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Erkelenz M; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany., Schluecker S; Department of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Essen, Germany., Merdanovic M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Poepsel S; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital, University of Cologne, Cologne, Germany; Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Germany., Hellerschmied D; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany., Burston SG; School of Biochemistry, University of Bristol, Bristol, United Kingdom., Ehrmann M; Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany. Electronic address: michael.ehrmann@uni-due.de. |
| Source: | The Journal of biological chemistry [J Biol Chem] 2025 Oct; Vol. 301 (10), pp. 110729. Date of Electronic Publication: 2025 Sep 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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