Benefits and risks of therapeutic hypothermia for hypoxic-ischemic encephalopathy in late preterm infants.

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Title: Benefits and risks of therapeutic hypothermia for hypoxic-ischemic encephalopathy in late preterm infants.
Authors: El-Dib M; Division of Newborn Medicine, Department of Pediatrics, Mass General Brigham for Children, Harvard Medical School, Boston, MA, USA. MEL-DIB@bwh.harvard.edu., Abdelgadir D; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Ahmad KA; Pediatrix Neonatology of San Antonio and Pediatrix Neonatology of Houston, Houston, TX, USA., Ayed M; Division of Neonatology, Maternity Hospital, Kuwait City, Kuwait., Burnsed J; Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA., Chavez-Valdez R; Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cizmeci MN; Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Craig A; Division of Pediatric Neurology, Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA., Groenendaal F; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University, Utrecht, The Netherlands., Gunn AJ; Department of Physiology, University of Auckland, Auckland, New Zealand., Kitsommart R; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Lancaster T; Department of Pediatrics, Overland Park Regional Medical Center, Overland Park, KS, USA., Lucke AM; Department of Pediatrics, Dell Medical School, University of Texas at Austin, and Pediatrix Medical Group, Austin, TX, USA., Malhotra A; Department of Paediatrics, Monash University, Melbourne, Australia., Marks JD; Section of Neonatology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Mathur A; Division of Neonatal- Perinatal Medicine, Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO, USA., Mietzsch U; Division of Neonatology, Department of Pediatrics, University of Washington Medical School, Seattle Children's Hospital, Seattle, WA, USA., Mohammad K; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada., Northington FJ; Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Peeples ES; Department of Pediatrics, University of Nebraska Medical Center and Children's Nebraska, Omaha, NE, USA., Shany E; Department of Pediatrics, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er Sheva, Israel., Sinha B; Department of Pediatrics, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Steggerda SJ; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands., Toso P; Department of Neonatology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile., Weiss M; Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA., Zanelli S; Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA., Inder T; Center for Neonatal Research, Children's Hospital of Orange County, Orange, and the Department of Pediatrics, University of California, Irvine, CA, USA.
Source: Pediatric research [Pediatr Res] 2026 Jun; Vol. 99 (5), pp. 1693-1697. Date of Electronic Publication: 2025 Sep 18.
Publication Type: Journal Article; Review
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22El-Dib+M%22">El-Dib M</searchLink>; Division of Newborn Medicine, Department of Pediatrics, Mass General Brigham for Children, Harvard Medical School, Boston, MA, USA. MEL-DIB@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Abdelgadir+D%22">Abdelgadir D</searchLink>; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.<br /><searchLink fieldCode="AU" term="%22Ahmad+KA%22">Ahmad KA</searchLink>; Pediatrix Neonatology of San Antonio and Pediatrix Neonatology of Houston, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ayed+M%22">Ayed M</searchLink>; Division of Neonatology, Maternity Hospital, Kuwait City, Kuwait.<br /><searchLink fieldCode="AU" term="%22Burnsed+J%22">Burnsed J</searchLink>; Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Chavez-Valdez+R%22">Chavez-Valdez R</searchLink>; Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cizmeci+MN%22">Cizmeci MN</searchLink>; Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Craig+A%22">Craig A</searchLink>; Division of Pediatric Neurology, Department of Pediatrics, Barbara Bush Children's Hospital at Maine Medical Center, Portland, ME, USA.<br /><searchLink fieldCode="AU" term="%22Groenendaal+F%22">Groenendaal F</searchLink>; Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, and Utrecht University, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Gunn+AJ%22">Gunn AJ</searchLink>; Department of Physiology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Kitsommart+R%22">Kitsommart R</searchLink>; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.<br /><searchLink fieldCode="AU" term="%22Lancaster+T%22">Lancaster T</searchLink>; Department of Pediatrics, Overland Park Regional Medical Center, Overland Park, KS, USA.<br /><searchLink fieldCode="AU" term="%22Lucke+AM%22">Lucke AM</searchLink>; Department of Pediatrics, Dell Medical School, University of Texas at Austin, and Pediatrix Medical Group, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+A%22">Malhotra A</searchLink>; Department of Paediatrics, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Marks+JD%22">Marks JD</searchLink>; Section of Neonatology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mathur+A%22">Mathur A</searchLink>; Division of Neonatal- Perinatal Medicine, Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Mietzsch+U%22">Mietzsch U</searchLink>; Division of Neonatology, Department of Pediatrics, University of Washington Medical School, Seattle Children's Hospital, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mohammad+K%22">Mohammad K</searchLink>; Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Northington+FJ%22">Northington FJ</searchLink>; Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Peeples+ES%22">Peeples ES</searchLink>; Department of Pediatrics, University of Nebraska Medical Center and Children's Nebraska, Omaha, NE, USA.<br /><searchLink fieldCode="AU" term="%22Shany+E%22">Shany E</searchLink>; Department of Pediatrics, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er Sheva, Israel.<br /><searchLink fieldCode="AU" term="%22Sinha+B%22">Sinha B</searchLink>; Department of Pediatrics, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Steggerda+SJ%22">Steggerda SJ</searchLink>; Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Toso+P%22">Toso P</searchLink>; Department of Neonatology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Weiss+M%22">Weiss M</searchLink>; Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Zanelli+S%22">Zanelli S</searchLink>; Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Inder+T%22">Inder T</searchLink>; Center for Neonatal Research, Children's Hospital of Orange County, Orange, and the Department of Pediatrics, University of California, Irvine, CA, USA.
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