Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.

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Title: Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.
Authors: Abdel Razek NS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt., Nassar NN; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Pharmacology and Toxicology, October University for Modern Science and Arts (MSA), Giza 12622, Egypt., Sayed RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Clinical Pharmacy, School of Pharmacy, Newgiza University, Giza 12577, Egypt., El-Sahar AE; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Biology, School of Pharmacy, Newgiza University, Giza 12577, Egypt., Abdallah DM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address: dalaal.abdallah@pharma.cu.edu.eg.
Source: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2025 Dec; Vol. 92, pp. 127755. Date of Electronic Publication: 2025 Sep 16.
Publication Type: Journal Article
Journal Info: Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE
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  Data: Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.
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  Data: <searchLink fieldCode="AU" term="%22Abdel+Razek+NS%22">Abdel Razek NS</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22Nassar+NN%22">Nassar NN</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Pharmacology and Toxicology, October University for Modern Science and Arts (MSA), Giza 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Sayed+RH%22">Sayed RH</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Clinical Pharmacy, School of Pharmacy, Newgiza University, Giza 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Sahar+AE%22">El-Sahar AE</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt; Department of Biology, School of Pharmacy, Newgiza University, Giza 12577, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdallah+DM%22">Abdallah DM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address: dalaal.abdallah@pharma.cu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%229508274%22">Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)</searchLink> [J Trace Elem Med Biol] 2025 Dec; Vol. 92, pp. 127755. <i>Date of Electronic Publication: </i>2025 Sep 16.
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      – TitleFull: Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.
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              Text: 2025 Dec
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