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Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.

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Title: Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.
Authors: Kapelyukh Y; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom., Gabel-Jensen C; Development ADME, Novo Nordisk A/S, Måløv, Denmark., MacLeod AK; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom., Daniel Coquelin KS; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Stojanovski L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom., Frame L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom., Tavendale A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom., Henderson CJ; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom., Wolf CR; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom. Electronic address: c.r.wolf@dundee.ac.uk., Säll C; Development ADME, Novo Nordisk A/S, Måløv, Denmark.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Oct; Vol. 53 (10), pp. 100153. Date of Electronic Publication: 2025 Aug 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.
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  Data: <searchLink fieldCode="AU" term="%22Kapelyukh+Y%22">Kapelyukh Y</searchLink>; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gabel-Jensen+C%22">Gabel-Jensen C</searchLink>; Development ADME, Novo Nordisk A/S, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22MacLeod+AK%22">MacLeod AK</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Daniel+Coquelin+KS%22">Daniel Coquelin KS</searchLink>; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.<br /><searchLink fieldCode="AU" term="%22Stojanovski+L%22">Stojanovski L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Frame+L%22">Frame L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tavendale+A%22">Tavendale A</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Henderson+CJ%22">Henderson CJ</searchLink>; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wolf+CR%22">Wolf CR</searchLink>; Cancer Research Division, University of Dundee Medical School, Dundee, United Kingdom. Electronic address: c.r.wolf@dundee.ac.uk.<br /><searchLink fieldCode="AU" term="%22Säll+C%22">Säll C</searchLink>; Development ADME, Novo Nordisk A/S, Måløv, Denmark.
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  Data: <searchLink fieldCode="JN" term="%229421550%22">Drug metabolism and disposition: the biological fate of chemicals</searchLink> [Drug Metab Dispos] 2025 Oct; Vol. 53 (10), pp. 100153. <i>Date of Electronic Publication: </i>2025 Aug 26.
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