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Accelerated Cognitive Decline in Late Life Depression: The Role of Amyloid-β, Cortico-Limbic Volume, and White Matter Hyperintensities.

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Title: Accelerated Cognitive Decline in Late Life Depression: The Role of Amyloid-β, Cortico-Limbic Volume, and White Matter Hyperintensities.
Authors: Rhodes E; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA; Department of Neurology, Frontotemporal Degeneration Center (ER), University of Pennsylvania, Philadelphia, PA., Insel PS; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA., Kassel M; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA., Kryza-Lacombe M; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA., Butters MA; Department of Psychiatry Western Psychiatric Hospital (MAB), University of Pittsburgh School of Medicine, Pittsburgh, PA., Bickford D; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA., Tosun D; Veterans Administration Medical Center (DT, RSM), San Francisco, CA; Department of Radiology and Biomedical Imaging (DT, MWW), University of California San Francisco, San Francisco, CA., Morin R; Hoag Memorial Hospital Presbyterian (RM), Newport Beach, CA., Aisen P; Department of Neurology, Keck School of Medicine (PA, RR), University of Southern California, Los Angeles, CA; Keck School of Medicine (PA), Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA., Rosen H; Department of Neurology, Memory and Aging Center (HR, RR), University of California, San Francisco, CA., Raman R; Department of Neurology, Keck School of Medicine (PA, RR), University of Southern California, Los Angeles, CA; Department of Neurology, Memory and Aging Center (HR, RR), University of California, San Francisco, CA., Landau S; Neuroscience Department, Helen Wills Neuroscience Institute (SL), University of California, Berkeley, CA., Saykin A; Department of Radiology and Imaging Sciences, Indiana University School of Medicine (AS), Indianapolis, IN., Toga AW; Laboratory of Neuro Imaging (AWT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA., Jack CR; Mayo Clinic (CRJ), Rochester, MN., Weiner MW; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA; Department of Radiology and Biomedical Imaging (DT, MWW), University of California San Francisco, San Francisco, CA., Nelson C; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA., Mackin RS; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA; Veterans Administration Medical Center (DT, RSM), San Francisco, CA. Electronic address: Scott.mackin@ucsf.edu.
Corporate Authors: Alzheimer’s Disease Neuroimaging Initiative
Source: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2026 Feb; Vol. 34 (2), pp. 183-194. Date of Electronic Publication: 2025 Aug 29.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Rhodes+E%22">Rhodes E</searchLink>; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA; Department of Neurology, Frontotemporal Degeneration Center (ER), University of Pennsylvania, Philadelphia, PA.<br /><searchLink fieldCode="AU" term="%22Insel+PS%22">Insel PS</searchLink>; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Kassel+M%22">Kassel M</searchLink>; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Kryza-Lacombe+M%22">Kryza-Lacombe M</searchLink>; Mental Illness Research Education and Clinical Centers (ER, MK, MKL), Veterans Administration Medical Center, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Butters+MA%22">Butters MA</searchLink>; Department of Psychiatry Western Psychiatric Hospital (MAB), University of Pittsburgh School of Medicine, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Bickford+D%22">Bickford D</searchLink>; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Tosun+D%22">Tosun D</searchLink>; Veterans Administration Medical Center (DT, RSM), San Francisco, CA; Department of Radiology and Biomedical Imaging (DT, MWW), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Morin+R%22">Morin R</searchLink>; Hoag Memorial Hospital Presbyterian (RM), Newport Beach, CA.<br /><searchLink fieldCode="AU" term="%22Aisen+P%22">Aisen P</searchLink>; Department of Neurology, Keck School of Medicine (PA, RR), University of Southern California, Los Angeles, CA; Keck School of Medicine (PA), Alzheimer's Therapeutic Research Institute, University of Southern California, San Diego, CA.<br /><searchLink fieldCode="AU" term="%22Rosen+H%22">Rosen H</searchLink>; Department of Neurology, Memory and Aging Center (HR, RR), University of California, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Raman+R%22">Raman R</searchLink>; Department of Neurology, Keck School of Medicine (PA, RR), University of Southern California, Los Angeles, CA; Department of Neurology, Memory and Aging Center (HR, RR), University of California, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Landau+S%22">Landau S</searchLink>; Neuroscience Department, Helen Wills Neuroscience Institute (SL), University of California, Berkeley, CA.<br /><searchLink fieldCode="AU" term="%22Saykin+A%22">Saykin A</searchLink>; Department of Radiology and Imaging Sciences, Indiana University School of Medicine (AS), Indianapolis, IN.<br /><searchLink fieldCode="AU" term="%22Toga+AW%22">Toga AW</searchLink>; Laboratory of Neuro Imaging (AWT), Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Jack+CR%22">Jack CR</searchLink>; Mayo Clinic (CRJ), Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Weiner+MW%22">Weiner MW</searchLink>; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA; Department of Radiology and Biomedical Imaging (DT, MWW), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Nelson+C%22">Nelson C</searchLink>; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Mackin+RS%22">Mackin RS</searchLink>; Department of Psychiatry and Behavioral Sciences (PSI, MK, DB, MWW, CN, RSM), University of California San Francisco, San Francisco, CA; Veterans Administration Medical Center (DT, RSM), San Francisco, CA. Electronic address: Scott.mackin@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%229309609%22">The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry</searchLink> [Am J Geriatr Psychiatry] 2026 Feb; Vol. 34 (2), pp. 183-194. <i>Date of Electronic Publication: </i>2025 Aug 29.
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