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Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.

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Title: Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.
Authors: Strong R; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Nelson JF; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA. nelsonj@uthscsa.edu., Bogue MA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Colca JR; Cirius Therapeutics, Inc, Kalamazoo, MI, USA., Denzel M; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9B, 50931, Cologne, Germany., Diaz V; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Finck BN; Division of Nutritional Sciences and Obesity Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., Gladyshev VN; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Horvath S; Human Genetics, David Geffen School of Medicine, UCLA. Epigenetic Clock Development Foundation, Los Angeles, CA, 90095, USA.; Altos Labs, Cambridge Institute, Granta Park, Cambridgeshire, CB21 6GP, UK., Jiang N; Department of Cellular and Integrative Physiology and Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Keller T; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA., Kletzien RF; Department of Biomedical Sciences, Metabolic Solutions Development Company (MSDC), Western Michigan University School of Medicine, KalamazooGrand Rapids, MI 49007.MI 49546 , USA., Korstanje R; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Kumar N; Division of Geriatric and Palliative Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Leeuwenburgh C; Institute On Aging, Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, 32611, USA., Fernandez E; Geriatric Research, Education and Clinical Center and Research Service, Department of Pharmacology, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Galecki A; Departments of Internal Medicine and Biostatistics, School of Medicine and School of Public Health, University of Michigan, Ann Arbor, MI, 48109-2200, USA., Ginsburg B; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Han M; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA., Kaczorowski C; Department of Neurology, University of Michigan, Ann Arbor, MI, 48109, USA., Leiser S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA., Lopez-Cruzan M; Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Raj K; Altos Labs, Cambridge Institute, Granta Park, Cambridgeshire, CB21 6GP, UK., Reifsnyder PC; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Rosenthal NA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; National Heart and Lung Institute, Imperial College London, London, UK., Rosi S; Altos Labs, Bay Area Institute, 13-Island Dr, Redwood City, CA, 94065, USA., Shindyapina A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Stacpoole P; Department of Medicine. Division of Endocrinology, Diabetes and Metabolism, University of Florida. , 1600 SW Archer Road Gainesville, Florida, 32610-0226, USA., Salmon AB; Geriatric Research, Education and Clinical Center, Department of Molecular Medicine, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA., Tyshkovskiy A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Walter P; Dept of Biochemistry & Biophysics, Howard Hughes Medical Institute, University of California San Francisco, MC2200. 600 16Th St, N316, San Francisco, CA, 94143, USA., Whitman M; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA., Miller RA; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA., Harrison DE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
Source: GeroScience [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4139-4156. Date of Electronic Publication: 2025 Sep 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.
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Division of Endocrinology, Diabetes and Metabolism, University of Florida. , 1600 SW Archer Road Gainesville, Florida, 32610-0226, USA.<br /><searchLink fieldCode="AU" term="%22Salmon+AB%22">Salmon AB</searchLink>; Geriatric Research, Education and Clinical Center, Department of Molecular Medicine, Barshop Institute for Longevity and Aging Studies, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.<br /><searchLink fieldCode="AU" term="%22Tyshkovskiy+A%22">Tyshkovskiy A</searchLink>; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Walter+P%22">Walter P</searchLink>; Dept of Biochemistry & Biophysics, Howard Hughes Medical Institute, University of California San Francisco, MC2200. 600 16Th St, N316, San Francisco, CA, 94143, USA.<br /><searchLink fieldCode="AU" term="%22Whitman+M%22">Whitman M</searchLink>; Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Miller+RA%22">Miller RA</searchLink>; Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, 48109, USA.<br /><searchLink fieldCode="AU" term="%22Harrison+DE%22">Harrison DE</searchLink>; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Jun; Vol. 48 (3), pp. 4139-4156. <i>Date of Electronic Publication: </i>2025 Sep 19.
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